Effect of VEGF and Minoxidil on the Production of Arachidonic Acid Metabolites by Cultured Hair Dermal Papilla Cells

This study investigated the production of arachidonic acid metabolites in hair dermal papilla cells (DPC) and the effects of minoxidil and vascular endothelial growth factor (VEGF) on this process. The research found that high concentrations of VEGF activated the production of eicosanoids, while a low concentration of minoxidil (12 μM) inhibited the production of prostaglandin 6KF 1α but stimulated the production of PGE 2 and LTB 4. These findings confirmed the role of VEGF and minoxidil in modulating eicosanoid production by DPC, suggesting their potential impact on hair growth and related biological activities.