Hair Follicle Expression of 1,25-Dihydroxyvitamin D3 Receptors During the Murine Hair Cycle

July 2006 in “ British Journal of Dermatology ”

J. Reichrath, M. Schilli, A. Kerber, F. A. Bahmer, B M Czarnetzki, R. Paus, J. Reichrath, M. Schilli, A. Kerber, F. A. Bahmer, B M Czarnetzki, R. Paus

TLDR Vitamin D receptors in hair follicles change with the hair cycle, affecting hair growth.

This study investigated the expression of vitamin D receptors (VDR) in hair follicles during the murine hair cycle, using C57 BL-6 mice. VDR expression was detected in both outer root sheath keratinocytes and dermal papilla cells, with stronger immunoreactivity observed during the anagen IV-VI and catagen phases compared to telogen and anagen I-III. These findings suggested that VDR expression varied with the hair cycle, indicating a potential role for 1,25-dihydroxyvitamin D3 in hair follicle biology and suggesting that certain follicular cell populations might have hair cycle-dependent sensitivity to this hormone.

View this study on doi.org →

Discuss this study in the Community →

Research cited in this study

4 / 4 results

research Glucocorticoid Effect on Hair Growth Initiation: A Reconsideration

77 citations , January 1993 in “Skin Pharmacology and Physiology”

Steroids stop hair growth temporarily but don't block the signals that start it.

research Hair Growth Inhibition by Heparin in Mice: A Model System for Studying the Modulation of Epithelial Cell Growth by Glycosaminoglycans

46 citations , May 1991 in “British Journal of Dermatology”

Heparin can inhibit hair growth in mice when injected.

research Topographical and Developmental Studies on Target Sites of 1,25 (OH)₂ Vitamin D₃ in Skin

70 citations , November 1984 in “Cell & tissue research/Cell and tissue research”

Vitamin D3 affects cell differentiation in specific skin areas.

research Growth of the Hair

521 citations , January 1954 in “Physiological Reviews”

Hair growth is cyclic and influenced mainly by local factors.

Related Research

5 / 5 results

A Review of Hair Anatomy and Animal Models for Alopecia

research Alopecia

January 2002 in “Journal of the Korean Medical Association”

Recent research has provided important insights into hair growth and hair loss treatments.

research Towards a Molecular Understanding of Hair Loss and Its Treatment

236 citations , July 2001 in “Trends in Molecular Medicine”

Future hair loss treatments should aim to extend hair growth, reactivate resting follicles, reverse shrinkage, and possibly create new follicles, with gene therapy showing promise.