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Glossary Vitamin D Receptor

protein that binds vitamin D to regulate gene expression

The Vitamin D Receptor (VDR) is a protein found in various cells throughout the body that binds to vitamin D, allowing it to regulate the expression of specific genes. This receptor plays a crucial role in maintaining calcium and phosphate balance, which is essential for healthy bone formation, and it also influences immune system function and hair follicle cycling.

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Research

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research Deletion of Deoxyribonucleic Acid Binding Domain of the Vitamin D Receptor Abrogates Genomic and Nongenomic Functions of Vitamin D

277 citations , July 2002 in “Molecular Endocrinology”

In this study, homozygous VDR null mutant mice exhibited nonfunctional vitamin D receptors, leading to growth abnormalities and revealing the limited physiological importance of vitamin D pathways outside the classical receptor.

research Lack of the Vitamin D Receptor is Associated with Reduced Epidermal Differentiation and Hair Follicle Growth

180 citations , January 2002 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study observed that vitamin D receptor knockout mice exhibit impaired epidermal differentiation and progressive hair loss, suggesting the importance of the vitamin D receptor in normal skin and hair follicle development.

research Atrichia Caused by Mutations in the Vitamin D Receptor Gene is a Phenocopy of Generalized Atrichia Caused by Mutations in the Hairless Gene

139 citations , September 2001 in “The journal of investigative dermatology/Journal of investigative dermatology”

This case report describes a patient with mutations in both alleles of the vitamin D receptor who exhibited hair loss clinically indistinguishable from generalized atrichia with papules, suggesting a potential genetic pathway shared with the hairless gene.

research Mutations in the vitamin D receptor and hereditary vitamin D-resistant rickets

107 citations , March 2014 in “BoneKEy Reports”

This abstract reviews hereditary vitamin D-resistant rickets, a rare genetic condition causing severe early childhood rickets, and reports no new results; effective treatment typically requires high doses of calcium to address hypocalcemia and secondary hyperparathyroidism.

research Cloning of a Functional Vitamin D Receptor from the Lamprey (Petromyzon marinus), an Ancient Vertebrate Lacking a Calcified Skeleton and Teeth

104 citations , May 2003 in “Endocrinology”

This study found that the vitamin D receptor in lampreys, which lack bones and hair, binds 1,25-dihydroxyvitamin D3 and may function to induce enzymes for detoxifying substances.

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Community Join

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community Is Vitamin D the cause of my baldness or slow regrowth?

in Is this regrowth? 1 upvotes 10 months ago

The conversation discusses hair loss treatments, including oral finasteride, topical minoxidil, and microneedling, and the potential impact of Vitamin D and folic acid deficiencies on hair regrowth. It suggests that while male pattern baldness is the primary cause, addressing vitamin deficiencies may aid in improving regrowth.

community Does drinking coffee have any effect on hairloss?

4 upvotes 5 years ago

Coffee's effect on hair loss is debated, with some suggesting it may exacerbate hair loss due to vasoconstriction, while others believe it could have positive effects. Topical caffeine might be beneficial, but ingesting it could potentially inhibit vitamin D receptors.

community What vitamin deficiencies that cause hair loss

54 upvotes 1 year ago

Vitamin deficiencies, particularly in vitamins A, B, C, D, and minerals like iron, zinc, and copper, can lead to hair loss. Dietary changes, such as eating more nutrient-rich foods, can improve hair health.

community South Korean Red Light Therapy Study

41 upvotes 7 months ago

Korean scientists developed a red light therapy that reduces a hair loss marker by 92%. Users discussed the benefits and drawbacks of natural sunlight versus red light caps for hair health, with some suggesting supplements for vitamin D.

community My Experience and a Discourse on "DUPA"

8 upvotes 2 years ago

The user discusses their hair loss experience, exploring various hypotheses including thyroid levels, vitamin D, DHEA, nutritional deficiency, diabetes, seborrheic dermatitis, lack of nutrition to hair follicles, chronic inflammation, female pattern hair loss causes, cortisol, and prolactin levels. They are currently using finasteride, beta-sitosterol, and have tried topical dutasteride and microneedling therapy.

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Learn

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learn Vitamin D

Vitamin made in the skin from sunlight, also taken as a supplement

What is the connection between Vitamin D and hair loss? Observational studies link low vitamin D with some types of hair loss, especially alopecia areata, but they have not shown that low vitamin D causes it.
Can Vitamin D deficiency trigger excessive hair shedding? Observational studies link low vitamin D with some kinds of shedding, but they have not shown that it causes it. A blood test and a doctor can check your level.
Is it safe to take Vitamin D supplements for hair growth? At normal doses vitamin D is well tolerated by most adults, but high doses can raise blood calcium. It has only been linked to hair in people who are deficient, so ask a doctor about a blood test first.
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learn Dexpanthenol

Provitamin B5, a moisturiser in hair and skin products

learn Calcium D oantothenate

learn Biotin

B vitamin, often sold as a hair supplement

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Clinics

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Hair Loss Treatments
IV Vitamin & Therapy LoungeSheffield, England · GB

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