TLDR Heparin can inhibit hair growth in mice when injected.
The study investigated the effects of heparin, a glycosaminoglycan, on hair growth in anagen-induced C57 Bl-6 mice. It was found that intraperitoneal administration of heparin inhibited the development of anagen follicles, while topical application did not have the same effect. Heparin influenced skin epithelial cell functions in a dose- and hair cycle-dependent manner, increasing the synthesis of arginine-rich proteins in the epidermis and reducing epithelial bulb cell proliferation. The effects varied based on the hair cycle stage and cell type. The study concluded that heparin could be a valuable tool for understanding the role of glycosaminoglycans in epithelial cell biology and hair growth.
66 citations
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August 1990 in “Journal of Investigative Dermatology” Epithelial cell growth in rat hair follicles needs contact with mesenchymal cells through the extracellular matrix.
65 citations
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October 1988 in “Clinics in dermatology” The dermal papilla interacts with the epidermis to control hair growth and development.
53 citations
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April 1985 in “Developmental Biology” Fibronectin and other basement membrane components increase during hair growth and decrease during rest.
3 citations
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June 1979 in “The Journal of Dermatology” Glycosaminoglycan levels peak early in hair growth and decrease as the cycle progresses.
186 citations
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October 1957 in “A M A Archives of Dermatology” Alopecia mucinosa is a challenging condition with unclear diagnosis and treatment.
1 citations
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January 2019 in “Elsevier eBooks” Electrospun matrices help regenerate skin and hair follicles using PCL and collagen scaffolds.
1 citations
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April 2023 in “Biomaterials advances” Gellan gum hydrogels help recreate the environment needed for hair growth cell function.
1160 citations
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November 2018 in “Physiological Reviews” The document concludes that better targeted treatments are needed for wound healing, and single-cell technologies may improve cell-based therapies.
14 citations
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October 2000 in “Genomics” Rat dermal papilla cells have unique genes crucial for hair growth.
127 citations
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March 2016 in “PLoS ONE” Key genes and pathways crucial for hair follicle development in cashmere goats were identified, aiding fleece production improvement.
