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    AP-2α/AP-2β Transcription Factors Are Key Regulators of Epidermal Homeostasis

    Hui Zhang, Jackelyn R. Raymundo, Kristian Daly … Alexander G. Marneros

    Preprint — not peer reviewed. This was posted to a preprint server or data repository. It has not been through a journal's review process, and its findings may change or not hold up.

    Studysummary This study found that AP-2α and AP-2β transcription factors are crucial for maintaining adult skin homeostasis, with their inactivation in keratinocytes leading to impaired differentiation, hair abnormalities, and inflammation, highlighting their key regulatory roles.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 3

    1. Molecular and Spatial Landmarks of Early Mouse Skin Development Developmental cell · 2023
    2. Beta-Catenin Activity in the Dermal Papilla Regulates Morphogenesis and Regeneration of Hair Developmental Cell · 2010
    3. Beyond Wavy Hairs: The Role of EGFR in Skin and Hair Biology American Journal Of Pathology · 2008

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    1. Development of Pigmented Reconstructed Human Epidermis Model Containing Human Melanoblasts from Keratinocyte Culture Journal of Investigative Dermatology · 2019