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Glossary CXCL1

small protein that attracts white blood cells to inflammation

CXCL1, also known as Chemokine (C-X-C motif) ligand 1 or GROα, is a small protein involved in the immune response. It acts as a signaling molecule that attracts white blood cells to sites of inflammation or injury, playing a crucial role in wound healing and immune defense. In the context of hair biology, CXCL1 can influence hair follicle cycling and may be involved in conditions like alopecia, where hair loss occurs.

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research Regulatory T cells in skin utilize the Cxcr4-Cxcl12 axis to promote hair follicle regeneration

October 2025 in “Cell Reports”

This study found that regulatory T cells accumulate in hair follicle epithelium via the Cxcr4-Cxcl12 axis, partially influenced by glucocorticoid receptor signaling, promoting hair regeneration; similar mechanisms were observed in human and murine skin.

research The chemokine SDF-1/CXCL12 regulates the migration of melanocyte progenitors in mouse hair follicles

57 citations , April 2009 in “Differentiation”

This study demonstrates that SDF-1/CXCL12 and CXCR4 signaling play a crucial role in directing the migration and positioning of melanoblasts in mouse hair follicle formation.

research CXCL12+ dermal fibroblasts promote neutrophil recruitment and host defense by recognition of IL-17

32 citations , January 2024 in “The Journal of Experimental Medicine”

This study found that CXCL12+ fibroblast subsets in mouse skin play a critical role in recruiting neutrophils and defending against S. aureus infection, with similar fibroblast activity observed in human psoriatic skin.

research Increased Circulating CXCL10 in Non-Segmental Vitiligo Concomitant with Autoimmune Thyroid Disease and Alopecia Areata

17 citations , January 2019 in “Annals of Dermatology”

This study found that higher serum CXCL10 levels may predict the progression of non-segmental vitiligo, especially in patients also suffering from autoimmune thyroid disease and/or alopecia areata.

research Polymorphisms in the promoter regions of the CXCL1 and CXCL2 genes contribute to increased risk of alopecia areata in the Korean population

8 citations , January 2015 in “Genetics and Molecular Research”

This study found that specific SNPs in the CXCL1 and CXCL2 genes may be associated with increased susceptibility to alopecia areata in the Korean population.

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