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Glossary CXCL10

signaling protein that attracts immune cells to inflammation sites

CXCL10, also known as Interferon gamma-induced protein 10 (IP-10), is a type of signaling protein called a chemokine. It plays a crucial role in the immune system by attracting white blood cells to sites of inflammation or infection. This protein is particularly important in conditions where the immune response needs to be regulated, such as autoimmune diseases and certain types of hair loss like alopecia areata.

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research Increased Circulating CXCL10 in Non-Segmental Vitiligo Concomitant with Autoimmune Thyroid Disease and Alopecia Areata

17 citations , January 2019 in “Annals of Dermatology”

This study found that higher serum CXCL10 levels may predict the progression of non-segmental vitiligo, especially in patients also suffering from autoimmune thyroid disease and/or alopecia areata.

research Polymorphisms in the promoter regions of the CXCL1 and CXCL2 genes contribute to increased risk of alopecia areata in the Korean population

8 citations , January 2015 in “Genetics and Molecular Research”

This study found that specific SNPs in the CXCL1 and CXCL2 genes may be associated with increased susceptibility to alopecia areata in the Korean population.

research Humanized CXCL12 antibody delays onset and modulates immune response in alopecia areata mice: insights from single-cell RNA sequencing

7 citations , October 2024 in “Frontiers in Immunology”

In this study, researchers prepared a humanized CXCL12 antibody for alopecia areata treatment, finding it significantly delayed disease onset in mice and reduced immune cell activation, suggesting potential as an immune modulatory therapy.

research Th1 Chemokine CXCL10 and Alopecia Areata: The Possible Target for the Treatment of Alopecia Areata

3 citations , January 2016 in “Journal of Clinical & Cellular Immunology”

In this study, increased production of CXCL10 was associated with the infiltration of Th1 and Tc1 cells in acute alopecia areata, suggesting a possible new target for treatment.

research CXCL12 Neutralizing Antibody Promotes Hair Growth in Androgenic Alopecia and Alopecia Areata

January 2024 in “International Journal of Molecular Sciences”

This study found that subcutaneous injection of a CXCL12 neutralizing antibody significantly promoted hair growth in androgenic alopecia and inhibited hair loss in alopecia areata in mouse models, suggesting its potential as a promising treatment for hair loss.

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