Development of Pigmented Reconstructed Human Epidermis Model Containing Human Melanoblasts from Keratinocyte Culture

April 2019 in “ Journal of Investigative Dermatology ”

Hyun Jung Choi, E. Cho, S. Lee, Il-Hong Bae, Daejin Min, Sejong Oh, Paulo A. Marinho, H. Kim

pigmented reconstructed human epidermis human melanoblasts keratinocyte culture calcium pulse method melanocytic cells epidermis skin pigmentation skin model melanoblasts keratinocytes calcium method pigmentation

Studysummary This study reported that gain-of-function mutations in TRPV3 lead to hair loss in mice by disrupting inner root sheath keratinocyte differentiation, ultimately causing follicular keratinocyte stem cell exhaustion and permanent follicle disruption.

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