Development of a Novel Three-Dimensional Human Epidermal Model from Plucked Hair Follicle-Derived Keratinocytes
TLDR Scientists created a new 3D skin model from cells of plucked hairs that works like real skin and is easier to get.
The document presents a study on the development of a novel three-dimensional (3D) human epidermal model using keratinocytes derived from plucked hair follicles. This method offers a less invasive alternative to traditional skin excision for obtaining keratinocytes. The new reconstructed human epidermis (RHE) model was compared to standard skin-derived models and found to be similar in morphology, genetic makeup, and function. The model's effectiveness was validated through staining of differentiation-related proteins, gene array analyses, and a skin irritation test recommended by the OECD. The study concluded that the RHE model from plucked hair follicle-derived keratinocytes provides a useful tool for investigating individual RHE in both normal and disease settings, offering a safer and simpler alternative to conventional methods.
