Gellan Gum-Based Hydrogels Support the Recreation of the Dermal Papilla Microenvironment

    April 2023 in “ Biomaterials advances
    Carla M. Abreu, Manuela E.L. Lago, Joana Pires, Rui L. Reis, Lucília P. da Silva, Alexandra P. Marques
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    TLDR Gellan gum hydrogels help recreate the environment needed for hair growth cell function.
    The study investigated the use of gellan gum-based hydrogels to recreate the dermal papilla (DP) microenvironment, a key factor in hair growth. The researchers found that stiffer hydrogels (1.25% vs 0.75% gellan gum) improved DP cell inductivity in short term cultures and supported basic hair morphogenesis events in a human skin model. The hydrogels were biofunctionalized with collagen IV or fibronectin-related peptides, and the type of peptide and gellan gum amount independently modulated the type and quantity of deposited extracellular matrix proteins. The study concluded that gellan gum-based hydrogels could be a promising tool for hair follicle regeneration and the evaluation of new candidate drugs for hair growth.
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