Bottom-Up Nanoencapsulation from Single Cells to Tunable and Scalable Cellular Spheroids for Hair Follicle Regeneration

February 2018 in “ Advanced Healthcare Materials ”

Jin Wang, Yong Miao, Yong Huang, Bojie Lin, Xiao Liu, Shune Xiao, Lijuan Du, Zhiqi Hu, Malcolm Xing

nanoencapsulation cellular spheroids hair follicle regeneration human dermal papilla cells human keratinocytes

TLDR Nanoencapsulation creates adjustable cell clusters for hair growth.

This document from 5 years ago explores the use of bottom-up nanoencapsulation to create cellular spheroids for hair follicle regeneration. The researchers found that this method allowed for the creation of tunable and scalable spheroids that could be used for hair regeneration. The study was conducted in vitro using human dermal papilla cells and human keratinocytes. The results suggest that this approach could be a promising strategy for hair regeneration in the future.

View this study on onlinelibrary.wiley.com →

Discuss this study in the Community →

Cited in this study

11 / 11 results

research Surface Tension Guided Hanging-Drop: Producing Controllable 3D Spheroids of High-Passaged Human Dermal Papilla Cells and Forming Inductive Microtissues for Hair-Follicle Regeneration

62 citations , February 2016 in “ACS Applied Materials & Interfaces”

Technique creates 3D cell spheroids for hair-follicle regeneration.

research Cytokine Loaded Layer-By-Layer Ultrathin Matrices to Deliver Single Dermal Papilla Cells for Spot-By-Spot Hair Follicle Regeneration

19 citations , January 2016 in “Journal of Materials Chemistry B”

Scientists have created a method to deliver specific cells that can regenerate hair follicles, potentially offering a new treatment for hair loss.

research Antimicrobial Peptide Lysozyme Has the Potential to Promote Mouse Hair Follicle Growth In Vitro

6 citations , October 2015 in “Acta histochemica”

Lysozyme might help mouse hair grow.

research Controllable Production of Transplantable Adult Human High-Passage Dermal Papilla Spheroids Using 3D Matrigel Culture

46 citations , September 2014 in “Tissue engineering. Part A”

Researchers created hair-inducing human cell clusters using a 3D culture method.

research Neonatal Murine Skin-Derived Cells Transplanted Using a Mini-Chamber Model Produce Robust and Normal Hair

9 citations , August 2013 in “Journal of Tissue Engineering and Regenerative Medicine”

Transplanted baby mouse skin cells grew normal hair using a new, efficient method.

research Scalable Production of Controllable Dermal Papilla Spheroids on PVA Surfaces and the Effects of Spheroid Size on Hair Follicle Regeneration

78 citations , January 2013 in “Biomaterials”

Larger spheroids improve hair growth, but size doesn't guarantee thicker hair.

research Large-Scale Cultivation of Transplantable Dermal Papilla Cellular Aggregates Using Microfabricated PDMS Arrays

25 citations , January 2011 in “Acta Biomaterialia”

Researchers developed a method to grow hair follicle cells for transplantation using a special chip.

research Review of Hair Follicle Dermal Cells

321 citations , January 2010 in “Journal of Dermatological Science”

Dermal cells are key in controlling hair growth and could potentially be used in hair loss treatments, but more research is needed to improve hair regeneration methods.

research Self-Assembly of Dermal Papilla Cells into Inductive Spheroidal Microtissues on Poly(Ethylene-Co-Vinyl Alcohol) Membranes for Hair Follicle Regeneration

80 citations , September 2008 in “Biomaterials”

EVAL membranes help create cell structures that can regrow hair follicles.

research Microencapsulated Human Hair Dermal Papilla Cells: A Substitute for Dermal Papilla?

25 citations , April 2008 in “Archives of Dermatological Research”

Encapsulated human hair cells can substitute for natural hair cells to grow hair.

research Molecular Mechanisms Regulating Hair Follicle Development

854 citations , February 2002 in “The journal of investigative dermatology/Journal of investigative dermatology”

Understanding hair follicle development can help treat hair loss, skin regeneration, and certain skin cancers.

1 / 1 results

research Bottom-Up Nanoencapsulation from Single Cells to Tunable and Scalable Cellular Spheroids for Hair Follicle Regeneration

30 citations , February 2018 in “Advanced Healthcare Materials”

Nanoencapsulation creates adjustable cell clusters for hair growth.