Antimicrobial Peptide Lysozyme Has the Potential to Promote Mouse Hair Follicle Growth In Vitro

The study investigated the potential of lysozyme, an antimicrobial peptide, to promote hair follicle growth in vitro using mouse models. Immunohistochemistry revealed that lysozyme was primarily expressed in the dermal papilla (DP) and dermal sheath (DS) regions of hair follicles, with its expression decreasing during the catagen phase. When hair follicles were treated with lysozyme (5-10 μg/ml) for 3 days, there was a significant enhancement in hair shaft elongation and an increase in the percentage of follicles in the anagen phase. The findings suggested that lysozyme played a role in anagen induction and was essential for hair growth in vitro. Further research was recommended to explore if similar effects could be observed in human hair, potentially offering a new tool for hair growth investigation.