Microencapsulated Human Hair Dermal Papilla Cells: A Substitute for Dermal Papilla?

April 2008 in “ Archives of Dermatological Research ”

Cheng Huang Lin, Yu Liu, JI Ying-chang, Keng Huang, Cai Xiang-na, Jin-kun Zhang

microencapsulated human hair dermal papilla cells dermal papilla hair follicle regeneration alginate-polylysine-alginate membrane sebaceous gland hair fibers dermis DP cells APA membrane

Studysummary This study found that transplanted microencapsulated dermal papilla cells in rat footpads can regenerate hair follicles and sebaceous gland structures, suggesting a potential substitute for fresh dermal papillae cells.

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In the 2008 study, researchers successfully demonstrated that microencapsulated human hair dermal papilla (DP) cells could act as a substitute for dermal papilla in hair follicle regeneration. By enclosing DP cells in an alginate-polylysine-alginate (APA) semipermeable membrane and implanting them into rat footpads, they observed the formation of hair follicle and sebaceous gland structures within 6-10 weeks, with hair fibers visible at 10 weeks. This suggests that microencapsulated DP cells retain their normal activity and can initiate follicle regeneration, offering a new method for studying hair growth mechanisms and the role of the dermis in this process.

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Research cited in this study

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research Hair Follicle Reformation Induced by Dermal Papilla Cells from Human Scalp Skin

32 citations , August 2006 in “Archives of Dermatological Research”

This study found that dermal papilla and sheath cells can induce hair follicle formation in vitro and in vivo by interacting with hair follicle epithelial cells.

research Differences in Hair Follicle Dermal Papilla Volume Are Due to Extracellular Matrix Volume and Cell Number: Implications for the Control of Hair Follicle Size and Androgen Responses

231 citations , December 1999 in “Journal of Investigative Dermatology”

This study found that the volume of a hair follicle's dermal papilla is strongly correlated with its size, primarily due to the number of cells it contains and the volume of extracellular matrix.

research Induction of Follicle Formation and Hair Growth by Vibrissa Dermal Papillae Implanted into Rat Ear Wounds: Vibrissa-Type Fibres Are Specified

125 citations , August 1992 in “Development”

This study found that implanting isolated adult rat dermal papillae into ear cuts led to the emergence of unusually large vibrissa-type hair follicles, demonstrating their capacity to induce specific hair fiber characteristics.

research The In Vitro Properties of Dermal Papilla Cell Lines Established From Human Hair Follicles

106 citations , April 1986 in “British Journal of Dermatology”

This study found that dermal papilla cells from human hair follicles form multi-layered aggregates when cultured in vitro, contrasting with the monolayer growth of dermal fibroblasts.