Who's tried these topical solutions? Treatment 8/24/2023
Topical melatonin, caffeine, and adenosine have shown impressive results in increasing hair density by 55% in 8 weeks, according to a Medium article.
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5 / 5 resultscommunity Growth stimulants worth a damn besides minox?
The user experiences side effects from minoxidil and is considering alternatives like stemoxydine and adenosine for hair regrowth and density, but finds options like caffeine and various oils unreliable. They are also using a 5AR inhibitor (finasteride).
community ~6-7 month progress. November 2025 - May 2026
The user experienced significant hair regrowth using finasteride alone over 6-7 months, despite initial side effects like reduced sexual desire and acne. They are considering reducing the dosage to manage side effects and have also used ketoconazole shampoo weekly.
community Looking for evidence-based additions to a 1% topical finasteride formulation
The conversation discusses enhancing a 1% topical finasteride solution for hair retention and regrowth with additional ingredients like melatonin, caffeine, and adenosine, while considering stability and efficacy. Concerns are raised about the stability of topical finasteride, with suggestions to use oral finasteride or obtain fresh formulations from a trusted pharmacy.
community What’s in Your 'Dream' Topical?
The conversation discusses creating a personalized topical treatment for hair loss, with ingredients like finasteride, minoxidil, tretinoin, melatonin, caffeine, and others. Users share their ideal formulations, including combinations of minoxidil, finasteride, tretinoin, adenosine, and other compounds, while also discussing the importance of managing inflammation.
community Galenic lotion. Science behind the components
A user is considering a hair loss treatment lotion containing minoxidil, adenosine, caffeine, melatonin, and azelaic acid, questioning the interaction between caffeine and adenosine receptors. Another user suggests adding a topical anti-DHT ingredient like spironolactone, noting it should not be taken orally by men.
Related Research
6 / 6 results
research Hair Changes Caused by Aging
Aging causes hair to gray and thin, with the timing of graying varying by race, and factors like oxidative stress and genetics can lead to hair loss.
research Ingredients of Trichological Shampoos with Alleged Beneficial Effects on Hair—What Is Really Known About Their Efficacy? A Scoping Review of an Area with More Unknowns than Knowns
This study found that of the many ingredients advertised in shampoos as effective against hair loss, only caffeine, adenosine, placental proteins, and melatonin have limited clinical evidence supporting their efficacy, with most claimed active ingredients lacking any trial-based validation.
research Anti‐hair loss effect of a shampoo containing caffeine and adenosine
This study found that while caffeine and adenosine can inhibit hair loss and stimulate hair growth, more research is needed to fully understand the efficacy of shampoo formulations containing specific proportions of these compounds for hair loss treatment and prevention.
research Androgenetic Alopecia: An Update on Pathogenesis and Pharmacological Treatment
This review article examines current drugs for androgenetic alopecia, focusing on their mechanisms and clinical efficacy, noting that while finasteride and minoxidil are commonly approved treatments, new drugs targeting different pathogenic pathways have emerged, offering a broader understanding and reference for AGA treatment options.
research Androgenetic Alopecia: An Evidence-Based Treatment Update
This review concluded that oral finasteride for men and topical minoxidil for both genders have the most evidence supporting their effectiveness and safety for treating androgenetic alopecia.
research Can plant‐derived phytochemicals provide symptom relief for hair loss? A critical review
This review discusses the potential benefits of phytochemicals for hair care and emphasizes the need for more robust preclinical and clinical studies, without reporting new clinical results.