Caffeine
Where to find Caffeine
Tracking 25 topical products by companies like Amazon, Hims, Keeps, MV supplements and Manual. View all 25 products »Caffeine, commonly associated with its stimulant effects, has been the subject of interest in the treatment of hair loss, particularly androgenetic alopecia. Its application in hair loss treatments stems from its potential to counteract the effects of hormones responsible for hair follicle shrinkage and to improve scalp health.
Research suggests that caffeine may be effective in treating common forms of hair loss by the inhibition of phosphodiesterase, improvement in barrier function, follicular penetration, stimulation and promotion of hair growth, and weakly counteracting the effects of dihydrotestosterone (DHT) on hair follicles. This action can potentially lead to increased hair growth and prevention of hair loss. Various in vitro, in vivo, and clinical trials have demonstrated caffeine's beneficial effects in promoting hair growth and increasing follicle diameter. Studies have also shown that caffeine may protect hair follicles from stress-related effects, suggesting a broader role in managing hair loss.
In the community, discussions around caffeine often revolve around its potential benefits and effectiveness. While some studies and user experiences suggest positive results with caffeine-containing products, such as shampoos and topical solutions, there is no overwhelming scientific consensus recommending caffeine compounds for hair regrowth. Users often discuss the role of caffeine in combination with other treatments like minoxidil and question its effectiveness due to its vasoconstrictive properties. Some individuals have experimented with caffeine shampoo and other caffeine-based products, with mixed feedback regarding their efficacy.
While research points to its potential benefits in promoting hair growth and improving scalp health, the community's experiences and opinions vary, highlighting the need for further studies to fully understand and validate caffeine's role in hair loss management.
Research
20 / 535 results![Caffeine’s Mechanisms of Action and Its Cosmetic Use](/images/research/f4995728-c96b-4931-b547-cc7e17586a52/small/25993.jpg)
research Caffeine’s Mechanisms of Action and Its Cosmetic Use
![Permeation of topically applied caffeine through human skin – a comparison of <i>in vivo</i> and <i>in vitro</i> data](/images/research/2d3a2a03-5e31-447c-b571-6abc6b523370/small/34074.jpg)
research Permeation of topically applied caffeine through human skin – a comparison of in vivo and in vitro data
![Differential effects of caffeine on hair shaft elongation, matrix and outer root sheath keratinocyte proliferation, and transforming growth factor‐β2/insulin‐like growth factor‐1‐mediated regulation of the hair cycle in male and female human hair follicles<i>in vitro</i>](/images/research/51cdd990-687f-43d4-b136-474148edd8fe/small/18768.jpg)
research Differential effects of caffeine on hair shaft elongation, matrix and outer root sheath keratinocyte proliferation, and transforming growth factor‐β2/insulin‐like growth factor‐1‐mediated regulation of the hair cycle in male and female human hair folliclesin vitro
![Effects of caffeine and siloxanetriol alginate caffeine, as anticellulite agents, on fatty tissue: histological evaluation](/images/research/abcab12a-0b1e-4b71-8fa5-fba2c2e27d16/small/35360.jpg)
research Effects of caffeine and siloxanetriol alginate caffeine, as anticellulite agents, on fatty tissue: histological evaluation
![Transepidermal <scp>UV</scp> radiation of scalp skin <i>ex vivo</i> induces hair follicle damage that is alleviated by the topical treatment with caffeine](/images/research/0000b672-335d-4c69-a6fb-6dbeac0ffdfd/small/25744.jpg)
research Transepidermal UV radiation of scalp skin ex vivo induces hair follicle damage that is alleviated by the topical treatment with caffeine
![An Open-Label Randomized Multicenter Study Assessing the Noninferiority of a Caffeine-Based Topical Liquid 0.2% versus Minoxidil 5% Solution in Male Androgenetic Alopecia](/images/research/82bac89b-e53e-4084-9584-b931fbc2cc38/small/4133.jpg)
research An Open-Label Randomized Multicenter Study Assessing the Noninferiority of a Caffeine-Based Topical Liquid 0.2% versus Minoxidil 5% Solution in Male Androgenetic Alopecia
![Investigation of transfollicular caffeine penetration using microdialysis on ex vivo porcine ear skin](/images/research/30d99ff1-71e8-461b-9074-728b7e481a33/small/33954.jpg)
research Investigation of transfollicular caffeine penetration using microdialysis on ex vivo porcine ear skin
![New effects of caffeine on corticotropin‐releasing hormone (CRH)‐induced stress along the intrafollicular classical hypothalamic–pituitary–adrenal (HPA) axis (CRH‐R1/2, IP<sub>3</sub>‐R, ACTH, MC‐R2) and the neurogenic non‐HPA axis (substance P, p75<sup>NTR</sup>and TrkA) in<i>ex vivo</i>human male androgenetic scalp hair follicles](/images/research/bd3b4fff-2da8-40d0-b183-984a889c2452/small/17452.jpg)
research New effects of caffeine on corticotropin‐releasing hormone (CRH)‐induced stress along the intrafollicular classical hypothalamic–pituitary–adrenal (HPA) axis (CRH‐R1/2, IP3‐R, ACTH, MC‐R2) and the neurogenic non‐HPA axis (substance P, p75NTRand TrkA) inex vivohuman male androgenetic scalp hair follicles
![Role of caffeine in the management of androgenetic alopecia](/images/research/604fb44d-dfe7-47ac-b0a2-e3a8aef2c53a/small/3192.jpg)
research Role of caffeine in the management of androgenetic alopecia
![Caffeine and Its Pharmacological Benefits in the Management of Androgenetic Alopecia: A Review](/images/research/db31fa63-1866-43a6-a236-69f8174420b7/small/4871.jpg)
research Caffeine and Its Pharmacological Benefits in the Management of Androgenetic Alopecia: A Review
![Caffeine content in newborn hair correlates with maternal dietary intake](/images/research/5da0173d-9447-41d8-8129-7fae919c5bbb/small/25740.jpg)
research Caffeine content in newborn hair correlates with maternal dietary intake
![Caffeine Induces Autophagy and Apoptosis in Auditory Hair Cells via the SGK1/HIF-1α Pathway](/images/research/f3cb6a5d-36e7-4767-b0b6-306d4bffa630/small/25741.jpg)
research Caffeine Induces Autophagy and Apoptosis in Auditory Hair Cells via the SGK1/HIF-1α Pathway
![Therapeutic use of caffeine in dermatology: A literature review](/images/research/53aacebf-80f3-4023-98a5-e6a1f4a1a053/small/17534.jpg)
research Therapeutic use of caffeine in dermatology: A literature review
research Caffeine docking studies with keratin: Implications for its cosmetic applications
![Caffeine relaxes hair follicles in androgenetic alopecia](/images/research/7b45dede-6dc4-4892-a281-db0d16305b02/small/5066.jpg)
research Caffeine relaxes hair follicles in androgenetic alopecia
![44578 Caffeine supplementation to improve hair growth: a systematic review](/images/research/8d76b5d3-1bee-4c41-bf0f-cdc2dba72afb/small/23369.jpg)
research 44578 Caffeine supplementation to improve hair growth: a systematic review
![LibGuides: L3Y2 Tutorial 2022 - critical thinking: Claim 5: Caffeine reduces hair loss](/images/research/7d3100e5-a45a-4a3f-8880-8493aaf1ea50/small/25737.jpg)
research LibGuides: L3Y2 Tutorial 2022 - critical thinking: Claim 5: Caffeine reduces hair loss
![Caffeine in Hair Care and Anticellulite Cosmetics: Sample Preparation, Solid-Phase Extraction, and HPLC Determination.](/images/research/aed7eb95-c94b-4194-b8dc-dccca72fa4cc/small/25739.jpg)
research Caffeine in Hair Care and Anticellulite Cosmetics: Sample Preparation, Solid-Phase Extraction, and HPLC Determination.
research Caffeine content in newborn hair correlates with maternal dietary intake
![910 Transepidermal UV radiation of human scalp skin induces distinctive hair follicle damage, which is mitigated by topical caffeine treatment](/images/research/826391d2-d1f0-44a4-a70c-488665009d76/small/25743.jpg)