Effects of Caffeine and Siloxanetriol Alginate Caffeine as Anticellulite Agents on Fatty Tissue: Histological Evaluation

In 2008, a study involving 20 Wistar female mice investigated the potential of caffeine and siloxanetriol alginate caffeine (SAC) as anticellulite agents. The mice were topically treated with different formulations for 21 days. The results indicated that an emulsion with caffeine reduced fatty cell diameter by 17%, but the addition of sodium benzoate did not affect cell diameter. An emulsion with SAC was more effective, reducing fatty cell diameter by 16% and the number of fatty cells by 26%. The study concluded that SAC in emulsion form could be a more effective treatment for cellulite than caffeine, especially when compared to gel forms or formulations with sodium benzoate, which inhibited caffeine's effectiveness. The research highlighted that emulsions are a better vehicle for these substances than gels.