Caffeine and Its Pharmacological Benefits in the Management of Androgenetic Alopecia: A Review

    January 2020 in “ Skin Pharmacology and Physiology ”
    Jörn Michael Völker, Nadine Koch, Maike Becker, Adolf Klenk
    Studysummary This article discusses the potential for topical caffeine as a natural alternative for treating androgenetic alopecia due to its ability to penetrate skin, but it reports no new clinical findings.
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    Research cited in this study 35

    1. Efficacy of a Cosmetic Phyto-Caffeine Shampoo in Female Androgenetic Alopecia Giornale italiano di dermatologia e venereologia · 2020
    2. The Psychosocial Burden of Alopecia Areata and Androgenetic Alopecia: A Cross-Sectional Multicentre Study Among Dermatological Outpatients in 13 European Countries Journal of the European Academy of Dermatology and Venereology · 2019
    3. Can Plant-Derived Phytochemicals Provide Symptom Relief for Hair Loss? A Critical Review International Journal of Cosmetic Science · 2019
    4. Evaluating Hair Growth Promoting Effects of Candidate Substances: A Review of Research Methods Journal of Dermatological Science · 2019
    5. Follicular Penetration of Caffeine from Topically Applied Nanoemulsion Formulations Containing Penetration Enhancers: In Vitro Human Skin Studies Skin pharmacology and physiology · 2018
    6. Experimental and Early Investigational Drugs for Androgenetic Alopecia Expert Opinion on Investigational Drugs · 2017
    7. An Open-Label Randomized Multicenter Study Assessing the Noninferiority of a Caffeine-Based Topical Liquid 0.2% Versus Minoxidil 5% Solution in Male Androgenetic Alopecia Skin Pharmacology and Physiology · 2017
    8. Hair Pull Test: Evidence-Based Update and Revision of Guidelines Journal of The American Academy of Dermatology · 2016
    9. Infantile Generalized Hypertrichosis Caused by Topical Minoxidil Anais Brasileiros de Dermatologia · 2016
    10. Towards a Consensus on How to Diagnose and Quantify Female Pattern Hair Loss – The Female Pattern Hair Loss Severity Index (FPHL-SI) Journal of The European Academy of Dermatology and Venereology · 2015
    11. Resting No More: Redefining Telogen, the Maintenance Stage of the Hair Growth Cycle Biological Reviews · 2014
    12. Differential Effects of Caffeine on Hair Shaft Elongation, Matrix and Outer Root Sheath Keratinocyte Proliferation, and Transforming Growth Factor-β2/Insulin-Like Growth Factor-1-Mediated Regulation of the Hair Cycle in Male and Female Human Hair Follicles In Vitro British Journal of Dermatology · 2014
    13. Androgenetic Alopecia Der Hautarzt · 2013
    14. Minoxidil Induced Hypertrichosis in a 2-Year-Old Child F1000Research · 2013
    15. Hair: What Is New in Diagnosis and Management? Dermatologic Clinics · 2012
    16. Role of Caffeine in the Management of Androgenetic Alopecia International Journal of Trichology · 2012
    17. Hair Follicles Contribute Significantly to Penetration Through Human Skin Only Shortly After Application as a Solvent Deposited Solid in Humans BJCP. British journal of clinical pharmacology/British journal of clinical pharmacology · 2011
    18. Analysis of the Penetration of a Caffeine Containing Shampoo Into the Hair Follicles by In Vivo Laser Scanning Microscopy Laser Physics · 2009
    19. Permeation of Topically Applied Caffeine Through Human Skin – A Comparison of In Vivo and In Vitro Data BJCP. British journal of clinical pharmacology/British journal of clinical pharmacology · 2009
    20. Diagnosis of Hair Disorders Seminars in Cutaneous Medicine and Surgery · 2009
    21. Hair Loss in Women: Comprehensive Overview and Treatment Options Seminars in Cutaneous Medicine and Surgery · 2009
    22. Hair Evaluation Methods: Merits and Demerits International Journal of Trichology · 2009
    23. The Role of Hair Follicles in the Percutaneous Absorption of Caffeine BJCP. British journal of clinical pharmacology/British journal of clinical pharmacology · 2007
    24. Investigation of the Penetration and Storage of a Shampoo Formulation Containing Caffeine into the Hair Follicles by In Vivo Laser Scanning Microscopy Laser Physics Letters · 2007
    25. Follicular Penetration of Topically Applied Caffeine via a Shampoo Formulation Skin Pharmacology and Physiology · 2007
    26. Effect of Caffeine and Testosterone on the Proliferation of Human Hair Follicles In Vitro International Journal of Dermatology · 2007
    27. Hair Follicles and Their Role in Skin Health Expert Review of Dermatology · 2006
    28. Caffeine Improves Barrier Function in Male Skin International Journal of Cosmetic Science · 2006
    29. Molecular Mechanisms of Androgenetic Alopecia Experimental Gerontology · 2002
    30. Male Androgenetic Alopecia Clinical and Experimental Dermatology · 2002
    31. Female Pattern Hair Loss Clinical and Experimental Dermatology · 2002
    32. Allergic Contact Dermatitis to Topical Minoxidil Solution: Etiology and Treatment Journal of The American Academy of Dermatology · 2002
    33. Incidence of Female Androgenetic Alopecia (Female Pattern Alopecia) Dermatologic Surgery · 2001
    34. The Biology of Hair Follicles The New England Journal of Medicine · 1999
    35. Human Hair Growth In Vitro: A Model for the Study of Hair Follicle Biology Journal of Dermatological Science · 1994

    Related research 9

    1. A Survey of Patient Attitudes Towards Topical Minoxidil in the Treatment of Hair Loss PubMed · 2022
    2. Sisaipho Alopecia Areata Treated With Tofacitinib and Oral Minoxidil JAAD case reports · 2022
    3. Efficacy of Systemic Minoxidil and Tofacitinib Combination in Treatment-Resistant Alopecia Universalis Journal of Cosmetic Dermatology · 2020
    4. Caffeine and Its Pharmacological Benefits in the Management of Androgenetic Alopecia: A Review Skin Pharmacology and Physiology · 2020
    5. The Use of Trichoscopy to Assess the Efficacy of Topical Minoxidil 2% Solution in Patients with Female Pattern Hair Loss Zagazig university medical journal · 2019
    6. The Efficacy of Topical Minoxidil for Non-Scarring Alopecia: A Systematic Review PubMed · 2019
    7. Off-Label Use of Topical Minoxidil in Alopecia: A Review American Journal of Clinical Dermatology · 2019
    8. Scalp Psoriasiform Contact Dermatitis with Acute Telogen Effluvium Due to Topical Minoxidil Treatment Skin appendage disorders · 2015
    9. Drug-Induced Hair Disorders Current Drug Safety · 2006