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This study observed that caffeine-containing shampoo can penetrate hair follicles to a depth of approximately 200 μm and remains detectable even after 24 hours, suggesting a potential long-term reservoir effect.

This study found that while caffeine and adenosine can inhibit hair loss and stimulate hair growth, more research is needed to fully understand the efficacy of shampoo formulations containing specific proportions of these compounds for hair loss treatment and prevention.

This study found that a caffeine-containing shampoo penetrated deeply into hair follicles in just two minutes and remained there for up to 48 hours, even after washing.

This study conducted a pre-formulation evaluation of a caffeine shampoo for androgenic alopecia treatment, finding that the formulation remains stable under various conditions, suggesting its viability for compounding.

This article discusses the potential for topical caffeine as a natural alternative for treating androgenetic alopecia due to its ability to penetrate skin, but it reports no new clinical findings.