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    An Open-Label Randomized Multicenter Study Assessing the Noninferiority of a Caffeine-Based Topical Liquid 0.2% Versus Minoxidil 5% Solution in Male Androgenetic Alopecia

    January 2017 in “ Skin Pharmacology and Physiology
    Rachita Dhurat, Jill Chitallia, Theodor W. May … Adolf Klenk
    Studysummary In this noninferiority study, researchers found that a 0.2% caffeine-based topical liquid was not less effective than 5% minoxidil solution in improving hair growth in men with androgenetic alopecia over six months.
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    Research cited in this study 11

    1. Androgenetic, Diffuse, and Senescent Alopecia in Men: Practical Evaluation and Management Current problems in dermatology · 2015
    2. Differential Effects of Caffeine on Hair Shaft Elongation, Matrix and Outer Root Sheath Keratinocyte Proliferation, and Transforming Growth Factor-β2/Insulin-Like Growth Factor-1-Mediated Regulation of the Hair Cycle in Male and Female Human Hair Follicles In Vitro British Journal of Dermatology · 2014
    3. Caffeine’s Mechanisms of Action and Its Cosmetic Use Skin Pharmacology and Physiology · 2012
    4. Minoxidil Use in Dermatology, Side Effects, and Recent Patents Recent Patents on Inflammation & Allergy Drug Discovery · 2012
    5. Evidence-Based Guideline for the Treatment of Androgenetic Alopecia in Women and Men Journal der Deutschen Dermatologischen Gesellschaft · 2011
    6. Follicular Penetration of Topically Applied Caffeine via a Shampoo Formulation Skin Pharmacology and Physiology · 2007
    7. Effect of Caffeine and Testosterone on the Proliferation of Human Hair Follicles In Vitro International Journal of Dermatology · 2007
    8. Bioengineering the Hair Follicle Organogenesis · 2007
    9. EEMCO Guidance for the Assessment of Hair Shedding and Alopecia Skin Pharmacology and Physiology · 2004
    10. A Randomized Clinical Trial of 5% Topical Minoxidil Versus 2% Topical Minoxidil and Placebo in the Treatment of Androgenetic Alopecia in Men Journal of The American Academy of Dermatology · 2002
    11. The Biology of Hair Follicles The New England Journal of Medicine · 1999

    Related research 1

    1. An Open-Label Randomized Multicenter Study Assessing the Noninferiority of a Caffeine-Based Topical Liquid 0.2% Versus Minoxidil 5% Solution in Male Androgenetic Alopecia Skin Pharmacology and Physiology · 2017