Analysis of the Penetration of a Caffeine Containing Shampoo Into the Hair Follicles by In Vivo Laser Scanning Microscopy

December 2009 in “ Laser Physics ”

Jürgen Lademann, Heike Richter, Sabine Schanzer, Adolf Klenk, Wolfram Sterry, Alexa Patzelt

caffeine hair follicles in vivo laser scanning microscopy topically applied substances

Studysummary This study observed that caffeine-containing shampoo can penetrate hair follicles to a depth of approximately 200 μm and remains detectable even after 24 hours, suggesting a potential long-term reservoir effect.

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research The Role of Hair Follicles in the Percutaneous Absorption of Caffeine

182 citations , December 2007 in “BJCP. British journal of clinical pharmacology/British journal of clinical pharmacology”

This study demonstrated that hair follicles significantly expedite the absorption of caffeine through the skin compared to interfollicular pathways.

research Topical Delivery of Retinyl Ascorbate

8 citations , November 2007 in “Skin Pharmacology and Physiology”

In this study, skin stretching significantly increased the delivery of retinyl ascorbate into the dermis, while sealing hair follicles did not affect absorption through native skin.

research Investigation of the Penetration and Storage of a Shampoo Formulation Containing Caffeine into the Hair Follicles by In Vivo Laser Scanning Microscopy

24 citations , February 2007 in “Laser Physics Letters”

This study found that a caffeine-containing shampoo penetrated deeply into hair follicles in just two minutes and remained there for up to 48 hours, even after washing.

research Follicular Penetration of Topically Applied Caffeine via a Shampoo Formulation

93 citations , January 2007 in “Skin Pharmacology and Physiology”

In this study, caffeine applied in a shampoo penetrated hair follicles faster and more effectively than through the skin surface within the first 20 minutes.

research Effect of Caffeine and Testosterone on the Proliferation of Human Hair Follicles In Vitro

114 citations , January 2007 in “International Journal of Dermatology”

This study found that caffeine can stimulate hair growth in vitro and counteract testosterone-induced growth suppression in hair follicles from male AGA patients.

research Investigation of Differences in Follicular Penetration of Particle- and Nonparticle-Containing Emulsions by Laser Scanning Microscopy

46 citations , May 2006 in “Laser Physics”

In this study, particles similar in size to keratin cells were surprisingly found to penetrate more efficiently into hair follicles due to a possible pumping effect from moving hairs.

research Variations of Hair Follicle Size and Distribution in Different Body Sites

405 citations , January 2004 in “Journal of Investigative Dermatology”

This study found that hair follicle characteristics vary significantly across different body sites, with the forehead and calf showing the highest potential follicular reservoirs, challenging previous assumptions about skin appendage distribution.