Caffeine as an Active Molecule in Cosmetic Products for Hair Loss: Its Mechanisms of Action in the Context of Hair Physiology and Pathology

Caffeine is being explored as a treatment for hair loss due to its ability to penetrate hair follicles effectively, increase cAMP levels, and act as an antioxidant, potentially counteracting hair follicle miniaturization. It targets hair follicle structures, stimulating cell growth and survival pathways. While clinical studies suggest caffeine's effectiveness, they often lack rigorous design, such as control groups and clear concentration data. Despite its promising safety profile, further research with robust study designs is needed to confirm caffeine's efficacy in managing hair loss, particularly in conditions like androgenetic alopecia.