Caffeine as an Active Molecule in Cosmetic Products for Hair Loss: Its Mechanisms of Action in the Context of Hair Physiology and Pathology

    January 2025 in “ Molecules ”
    Ewelina Szendzielorz, Radosław Śpiewak
    Studysummary In this review, the authors discuss caffeine's potential mechanisms and benefits as a hair loss treatment, noting its possible effectiveness and safety, though they caution that existing studies often have significant design flaws.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 44

    1. Nanotechnology-Driven Delivery of Caffeine Using Ultradeformable Liposomes-Coated Hollow Mesoporous Silica Nanoparticles for Enhanced Follicular Delivery and Treatment of Androgenetic Alopecia International Journal of Molecular Sciences · 2024
    2. Placental Extracts, Proteins, and Hydrolyzed Proteins as Active Ingredients in Cosmetic Preparations for Hair Loss: A Systematic Review of Available Clinical Evidence Applied Sciences · 2024
    3. Dermal Papilla Cells: From Basic Research to Translational Applications Biology · 2024
    4. New Insight for Enhanced Topical Targeting of Caffeine for Effective Cellulite Treatment: In Vitro Characterization, Permeation Studies, and Histological Evaluation in Rats AAPS PharmSciTech · 2024
    5. Bioactives in Nutricosmetics: A Focus on Caffeine from Tea to Coffee Cosmetics · 2024
    6. Skin Development And Disease: A Molecular Perspective Current Issues in Molecular Biology · 2024
    7. Anti-Hair Loss Effect of a Shampoo Containing Caffeine and Adenosine Journal of cosmetic dermatology · 2024
    8. Management of Androgenic Alopecia: A Systematic Review of the Literature Journal of cosmetic and laser therapy · 2024
    9. Deciphering the Molecular Mechanisms of Stem Cell Dynamics in Hair Follicle Regeneration 2024
    10. An Analysis of the Presence of Ingredients Declared as Active in Trichological Shampoos for Hair Loss Estetologia Medyczna i Kosmetologia · 2024
    11. Controlling Hair Loss by Regulating Apoptosis in Hair Follicles: A Comprehensive Overview Biomolecules · 2023
    12. Safety and Efficacy of Hair Growth Promoting Product in Adult Human Subjects With Alopecia Journal of Cosmetic Dermatology · 2023
    13. Assessment of the Efficacy and Tolerability of a Topical Formulation Containing Caffeine and Procapil 3% for Improvement of Male Pattern Hair Loss Journal of Cosmetic Dermatology · 2023
    14. Hair Growth Promotion and Anti-Hair Loss Effects of Arabica Coffee Pulp Extracts Using Supercritical Fluid Extraction Foods · 2023
    15. Bioactive Compound-Loaded Nanocarriers for Hair Growth Promotion: Current Status and Future Perspectives Plants · 2023
    16. Follicular Delivery of Caffeine from a Shampoo for Hair Retention Cosmetics · 2023
    17. Overview of the Circadian Clock in the Hair Follicle Cycle Biomolecules · 2023
    18. Overview of Caffeine Effects on Human Health and Emerging Delivery Strategies Preprints.org · 2023
    19. Real-World, Open-Label Study of the Efficacy and Safety of a Novel Serum in Androgenetic Alopecia Journal of Drugs in Dermatology · 2023
    20. Integrative and Mechanistic Approach to the Hair Growth Cycle and Hair Loss Journal of Clinical Medicine · 2023
    21. Effect of Coffee Berry Extract on Anti-Aging for Skin and Hair: In Vitro Approach Cosmetics · 2022
    22. Morphogenesis, Growth Cycle, and Molecular Regulation of Hair Follicles Frontiers in Cell and Developmental Biology · 2022
    23. Recreation of a Hair Follicle Regenerative Microenvironment: Successes and Pitfalls Bioengineering & translational medicine · 2021
    24. Reduction of Telogen Rate and Increase of Hair Density in Androgenetic Alopecia by a Cosmetic Product: Results of a Randomized, Prospective, Vehicle-Controlled Double-Blind Study in Men Journal of Cosmetic Dermatology · 2021
    25. Immune Cell Regulation of the Hair Cycle Experimental Dermatology · 2020
    26. An Occurrence Analysis of Ingredients Declared as Active in Anti-Hair Loss Products and Systematic Review of Studies on Their Effectiveness Estetologia Medyczna i Kosmetologia · 2020
    27. Caffeine and Its Pharmacological Benefits in the Management of Androgenetic Alopecia: A Review Skin Pharmacology and Physiology · 2020
    28. Formononetin: Novel Treatment for Androgenetic Alopecia Archives of Medical Research · 2020
    29. The Dynamics of the Skin’s Immune System International Journal of Molecular Sciences · 2019
    30. Adverse Effects with Finasteride 5 mg/Day for Patterned Hair Loss in Premenopausal Women International Journal of Trichology · 2018
    31. Development of a Two-Dimensional Model for Predicting Transdermal Permeation with the Follicular Pathway: Demonstration with a Caffeine Study Pharmaceutical research · 2017
    32. An Open-Label Randomized Multicenter Study Assessing the Noninferiority of a Caffeine-Based Topical Liquid 0.2% Versus Minoxidil 5% Solution in Male Androgenetic Alopecia Skin Pharmacology and Physiology · 2017
    33. Androgenetic Alopecia: An Evidence-Based Treatment Update American Journal of Clinical Dermatology · 2014
    34. Differential Effects of Caffeine on Hair Shaft Elongation, Matrix and Outer Root Sheath Keratinocyte Proliferation, and Transforming Growth Factor-β2/Insulin-Like Growth Factor-1-Mediated Regulation of the Hair Cycle in Male and Female Human Hair Follicles In Vitro British Journal of Dermatology · 2014
    35. Comparing the Effectiveness of Local Solution of Minoxidil and Caffeine 2.5% with Local Solution of Minoxidil 2.5% in Treatment of Androgenetic Alopecia Journal of Mazandaran University of Medical Sciences · 2013
    36. Caffeine’s Mechanisms of Action and Its Cosmetic Use Skin Pharmacology and Physiology · 2012
    37. Permeation of Topically Applied Caffeine Through Human Skin – A Comparison of In Vivo and In Vitro Data BJCP. British journal of clinical pharmacology/British journal of clinical pharmacology · 2009
    38. Investigation of Drug Partition Property in Artificial Sebum International Journal of Pharmaceutics · 2007
    39. Investigation of the Penetration and Storage of a Shampoo Formulation Containing Caffeine into the Hair Follicles by In Vivo Laser Scanning Microscopy Laser Physics Letters · 2007
    40. Scratching the Surface of Skin Development Nature · 2007
    41. Follicular Penetration of Topically Applied Caffeine via a Shampoo Formulation Skin Pharmacology and Physiology · 2007
    42. Effect of Caffeine and Testosterone on the Proliferation of Human Hair Follicles In Vitro International Journal of Dermatology · 2007
    43. Transfollicular Drug Delivery: Is It a Reality? International journal of pharmaceutics · 2005
    44. Variations of Hair Follicle Size and Distribution in Different Body Sites Journal of Investigative Dermatology · 2004

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