Hair Growth Promotion and Anti-Hair Loss Effects of Arabica Coffee Pulp Extracts Using Supercritical Fluid Extraction

November 2023 in “ Foods ”

Anurak Muangsanguan, Pichchapa Linsaenkart, Tanakarn Chaitep, Jiraporn Sangta, Sarana Rose Sommano, Korawan Sringarm, Chaiwat Arjin, Pornchai Rachtanapun, Kittisak Jantanasakulwong, Yuthana Phimolsiripol, Juan Manuel Castagnini, Warintorn Ruksiriwanich

TLDR Arabica coffee pulp extract may help prevent hair loss and promote hair growth.

The study investigated the potential of Arabica coffee pulp extracts in promoting hair growth and preventing hair loss. Six extracts were obtained using supercritical fluid extraction (SFE), with the SFE-4 extract showing the highest phenolic, flavonoid, and caffeine contents. This extract increased the migration and cell proliferation of human hair follicle dermal papilla cells (HFDPCs), which control hair cycle regulation, and had scavenging effects on ABTS and DPPH radicals. It also decreased the expression of SRD5A1, SRD5A2, and SRD5A3, pathways involved in androgenetic alopecia (AGA), and activated hair growth factor genes in the Wnt/-catenin (CTNNB1) and Sonic Hedgehog (SHH, SMO, and GLI1) pathways. The results suggest that SFE in coffee pulp extraction could help AGA treatment by preventing hair loss and promoting hair growth pathways.

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