Collagenase IV Plays an Important Role in Regulating Hair Cycle by Inducing VEGF, IGF-1, and TGF-β Expression.

January 2015 in “ PubMed ”

Chun Hou, Yong Miao, Jin Wang, Xue Wang, Chao-Yue Chen, Zhiqi Hu

collagenase IV MMP-2 MMP-9 VEGF IGF-1 TGF-β hair cycle hair growth vascular endothelial growth factor insulin-like growth factor 1 transforming growth factor beta

TLDR Collagenase IV helps control hair growth by affecting certain growth factors.

The study suggested that type IV collagenases, specifically MMP-2 and MMP-9, played significant roles in regulating the hair cycle. This regulation was potentially mediated through the induced expression of VEGF, IGF-1, and TGF-β, which are factors known to influence hair growth and cycling.

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