The Role of the Hairless (Hr) Gene in the Regulation of Hair Follicle Catagen Transformation

    July 1999 in “ American Journal Of Pathology ”
    Andrey A. Panteleyev, Natalia V. Botchkareva, John P. Sundberg … Ralf Paus
    Studysummary This study found that the loss of a functional hr gene in mice leads to premature and abnormal hair follicle regression, disrupting normal hair cycling and architecture.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on ajp.amjpathol.org →
    Discuss this study in the Community →

    Research cited in this study 16

    1. Principles of Hair Cycle Control The Journal of Dermatology · 1998
    2. A Missense Mutation in the Zinc-Finger Domain of the Human Hairless Gene Underlies Congenital Atrichia in a Family of Irish Travellers The American Journal of Human Genetics · 1998
    3. Molecular and Functional Aspects of the Hairless (Hr) Gene in Laboratory Rodents and Humans Experimental Dermatology · 1998
    4. Towards Defining the Pathogenesis of the Hairless Phenotype Journal of Investigative Dermatology · 1998
    5. Alopecia Universalis Associated With a Mutation in the Human Hairless Gene Science · 1998
    6. Immunohistochemical Analysis of Tissue Remodeling During the Anagen-Catagen Transition of the Human Hair Follicle British Journal of Dermatology · 1997
    7. Immunohistochemical Analysis of Tissue Remodeling During the Anagen-Catagen Transition of the Human Hair Follicle British Journal of Dermatology · 1997
    8. Keratin 17 Gene Expression During the Murine Hair Cycle Journal of Investigative Dermatology · 1997
    9. Dermal-Epidermal Interactions in Hair Follicle Development and Maintenance Dermatologic clinics · 1996
    10. A Murine Model for Inducing and Manipulating Hair Follicle Regression: Effects of Dexamethasone and Cyclosporin A Journal of Investigative Dermatology · 1994
    11. Dynamic Expression Patterns of Tenascin, Proteoglycans, and Cell Adhesion Molecules During Human Hair Follicle Morphogenesis Developmental dynamics · 1994
    12. A New Look Into an Old Problem: Keratins as Tools to Investigate Determination, Morphogenesis, and Differentiation in Skin Genes & Development · 1989
    13. Outer Root Sheath Keratinization in Anagen and Catagen of the Mammalian Hair Follicle: A Seventh Distinct Type of Keratinization in the Hair Follicle - Trichilemmal Keratinization PubMed · 1981
    14. Morphogenesis of the Hair Follicle During Catagen Cell and Tissue Research · 1970
    15. Growth of the Hair Physiological Reviews · 1954
    16. The Expression And Interaction Of Hereditary Factors Producing Hypotrichosis In The Mouse: Histology And Experimental Results Canadian Journal of Research/Canadian journal of research · 1946