The Hair Loss Encyclopedia

Immunohistochemical Analysis of Tissue Remodeling During the Anagen-Catagen Transition of the Human Hair Follicle

July 1997 in “ British Journal of Dermatology ”

S Commo, Bruno Bernard

TLDR The inner root sheath is vital for hair follicle stability during growth changes.

The study investigated the transition from the anagen (growth) phase to the catagen (involution) phase in human hair follicles, focusing on tissue remodeling. Using monoclonal antibodies, researchers tracked changes in key hair follicle compartments. They found that the inner root sheath was an early target during the catagen phase, indicating its crucial role in maintaining hair follicle homeostasis.

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Research cited in this study

8 / 8 results

research Existence of Trichohyalin-Keratohyalin Hybrid Granules: Co-Localization of Two Major Intermediate Filament-Associated Proteins in Non-Follicular Epithelia

54 citations , November 1994 in “Differentiation”

Trichohyalin is found in non-hair tissues and works with filaggrin in certain skin areas and conditions.

research Immunohistochemical Demonstration of Keratin 19 Expression in Isolated Human Hair Follicles

43 citations , August 1994 in “Journal of Investigative Dermatology”

research Use of Gamma-Glutamyl Transpeptidase Activity as a Marker of Hair Cycle and Anagen Induction in Mouse Hair Follicles

14 citations , July 1994 in “Journal of Investigative Dermatology”

research Expression of the Bcl-2 Proto-Oncogene in the Cycling Adult Mouse Hair Follicle

122 citations , July 1994 in “Journal of Investigative Dermatology”

research The Structure of Human Trichohyalin: Potential Multiple Roles as a Functional EF-Hand-Like Calcium-Binding Protein, a Cornified Cell Envelope Precursor, and an Intermediate Filament-Associated (Cross-Linking) Protein

161 citations , June 1993 in “Journal of Biological Chemistry”

Trichohyalin helps in hair and skin cell structure and function by binding calcium and linking proteins.

research Expression of Calcyclin, a Calcium-Binding Protein, in the Keratogenous Region of Growing Hair Follicles

40 citations , March 1991 in “Journal of Investigative Dermatology”

research Expression of Basement Membrane Proteins and Interstitial Collagens in Dermal Papillae of Human Hair Follicles

85 citations , January 1991 in “Journal of Investigative Dermatology”

research Expression of keratin K14 in the epidermis and hair follicle: insights into complex programs of differentiation.

198 citations , November 1989 in “The Journal of Cell Biology”

Keratin K14 expression varies between hair follicles and epidermis, affecting cell differentiation.