Immunohistochemical Analysis of Tissue Remodeling During the Anagen-Catagen Transition of the Human Hair Follicle

The study investigated the transition from the anagen (growth) phase to the catagen (involution) phase in human hair follicles, focusing on tissue remodeling. Researchers used monoclonal antibodies to track changes in key hair follicle compartments, such as K14 keratin, trichohyalin, transglutaminase I, desmoglein, and Ki67 antigen. They found that the inner root sheath was an early target during the catagen phase, indicating its crucial role in maintaining hair follicle homeostasis. This research provided insights into the morphological changes and dynamics of hair follicle involution, although the complete mechanisms remained largely unknown.