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GlossaryDesmoglein

protein aiding cell adhesion in skin and tissues

Desmoglein is a type of protein found in the skin and other tissues that helps cells stick together, forming strong connections called desmosomes. These proteins are crucial for maintaining the structural integrity of tissues, and their dysfunction can lead to skin disorders and diseases such as pemphigus, where the skin becomes fragile and blisters easily.

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Localized Hypotrichosis Type 1 Due to Intragenic Deletion of Exons 5-8 in Desmoglein Gene in a Neonate from Indian Family

research Localized Hypotrichosis Type 1 Due to Intragenic Deletion of Exons 5-8 in Desmoglein Gene in a Neonate from Indian Family

August 2023 in “Acta Scientific Paediatrics”

A baby from an Indian family had a rare genetic disorder causing no scalp or body hair due to a specific gene deletion.

RPGRIP1L Facilitates Desmosomal Adhesion Through Suppressing PKCβII-Mediated Desmoglein Endocytosis: Implication in Pemphigus

research RPGRIP1L Facilitates Desmosomal Adhesion Through Suppressing PKCβII-Mediated Desmoglein Endocytosis: Implication in Pemphigus

April 2016 in “The journal of investigative dermatology/Journal of investigative dermatology”

RPGRIP1L helps skin cells stick together by blocking PKCβII, which can prevent skin blistering like in pemphigus.

research Immunolocalization of Junctional Proteins in Human Hairs Indicates That the Membrane Complex Stabilizes the Inner Root Sheath While Desmosomes Contact the Companion Layer Through Specific Keratins

12 citations , January 2013 in “Acta Histochemica”

Junctional proteins stabilize the inner root sheath and connect the companion layer in human hair.

research Dysfunction of Keratinocyte Adhesion

2 citations , September 2004 in “Experimental Dermatology”

Keratinocyte adhesion problems can cause skin and hair disorders.

research Intercellular Junctions in Normal Epidermis

2 citations , September 2004 in “Experimental Dermatology”

Desmosomal adhesion is essential for healthy skin structure and function.

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