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GlossaryDesmoglein

protein aiding cell adhesion in skin and tissues

Desmoglein is a type of protein found in the skin and other tissues that helps cells stick together, forming strong connections called desmosomes. These proteins are crucial for maintaining the structural integrity of tissues, and their dysfunction can lead to skin disorders and diseases such as pemphigus, where the skin becomes fragile and blisters easily.

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Suprabasal Desmoglein 3 Expression in the Epidermis of Transgenic Mice Results in Hyperproliferation and Abnormal Differentiation

research Suprabasal Desmoglein 3 Expression in the Epidermis of Transgenic Mice Results in Hyperproliferation and Abnormal Differentiation

108 citations, July 2002 in “Molecular and cellular biology”

Overexpressing Dsg3 in mice skin causes excessive cell growth and abnormal skin development.

research Mutations in the Desmoglein 4 Gene Are Associated with Monilethrix-Like Congenital Hypotrichosis

74 citations, January 2006 in “The journal of investigative dermatology/Journal of investigative dermatology”

Mutations in the DSG4 gene can cause a rare hair disorder similar to monilethrix.

research The Lanceolate Hair Rat Phenotype Results from a Missense Mutation in a Calcium Coordinating Site of the Desmoglein 4 Gene

50 citations, February 2004 in “Genomics”

A gene mutation causes lanceolate hair in rats by disrupting hair shaft integrity.

research Desmoglein 4 Is Regulated by Transcription Factors Implicated in Hair Shaft Differentiation

35 citations, August 2009 in “Differentiation”

Desmoglein 4 is controlled by specific proteins that affect hair growth.

research Smad4-Dependent Desmoglein-4 Expression Contributes to Hair Follicle Integrity

28 citations, July 2008 in “Developmental Biology”

Smad4 is important for healthy hair follicles because it helps produce a protein needed for hair to stick together and grow.

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