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    Glossary Desmosomal Components

    proteins and structures that hold cells together in tissues

    Desmosomal components are the proteins and structures that make up desmosomes, which are specialized cell junctions that help hold cells together, particularly in tissues that experience a lot of stress, like the skin and heart. These components include desmogleins and desmocollins (types of cadherins), as well as plakoglobin and desmoplakin, which link the cell membrane to the internal cytoskeleton, providing mechanical strength and stability.

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      Biology and Genetics of Hair

      research Biology and Genetics of Hair

      89 citations , September 2010 in “Annual Review of Genomics and Human Genetics”
      This review discusses the genetic factors involved in hair follicle morphogenesis and cycling and reports no new clinical results; it emphasizes the role of genes in hereditary hair diseases.
      Loose Anagen Hair as a Cause of Hereditary Hair Loss in Children

      research Loose Anagen Hair as a Cause of Hereditary Hair Loss in Children

      55 citations , October 1992 in “Archives of Dermatology”
      In this study, researchers observed that loose anagen hair syndrome is an autosomal dominant disorder characterized by abnormal hair follicle structure and premature keratinization, possibly due to signaling and desmosomal component disturbances.
      Congenital Hair Loss Disorders: Rare, But Not Too Rare

      research Congenital hair loss disorders: Rare, but not too rare

      41 citations , November 2011 in “The Journal of Dermatology”
      This review identifies genetic mutations associated with congenital hair loss disorders in Japanese populations, particularly highlighting common LIPH gene mutations linked to woolly hair/hypotrichosis, and reports no new clinical results.
      Recent Advances in Congenital Ichthyoses

      research Recent advances in congenital ichthyoses

      10 citations , July 2015 in “Current opinion in pediatrics, with evaluated MEDLINE/Current opinion in pediatrics”
      This review discusses updates in the genetics and clinical understanding of congenital ichthyosis and highlights the addition of N-acetylcysteine and topical enzyme replacement to the treatment options, without providing new clinical results.
      Molecular Genetics of Alopecias

      research Molecular Genetics of Alopecias

      9 citations , January 2015 in “Current problems in dermatology”
      This review highlights recent genetic research advancements in understanding hereditary hair diseases but reports no new study results, emphasizing the identification of genes related to both monogenic and polygenic hair disorders.
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