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GlossaryDesmosomes

specialized cell structures that glue adjacent cells together

Desmosomes are specialized structures in the cell membrane that act like glue, holding cells together, particularly in tissues that experience a lot of stress, such as skin and heart muscle. They are composed of proteins that link the cytoskeletons of adjacent cells, providing mechanical strength and stability to tissues.

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research Ichthyosis Follicularis with Alopecia and Photophobia in a Mother and Daughter

36 citations, January 2000 in “British journal of dermatology/British journal of dermatology, Supplement”

A mother and daughter had severe skin, hair, and eye issues linked to IFAP.

research Histopathological and Ultrastructural Study of Ectodermal Dysplasia/Skin Fragility Syndrome

31 citations, August 2005 in “The American Journal of Dermatopathology”

The study concluded that PKP1 is essential for skin integrity and hair growth, and its dysfunction causes the symptoms of ectodermal dysplasia/skin fragility syndrome.

research Regulation of Hair Shedding by the Type 3 IP3 Receptor

19 citations, May 2012 in “The journal of investigative dermatology/Journal of investigative dermatology”

The type 3 IP3 receptor is important for controlling hair loss and growth.

Structural and Biochemical Changes Underlying a Keratoderma-Like Phenotype in Mice Lacking Suprabasal AP1 Transcription Factor Function

research Structural and Biochemical Changes Underlying a Keratoderma-Like Phenotype in Mice Lacking Suprabasal AP1 Transcription Factor Function

17 citations, February 2015 in “Cell Death and Disease”

Inhibiting AP1 in mice skin causes structural changes and weakens the skin barrier.

research Hair Loss in Autoimmune Cutaneous Bullous Disorders

12 citations, May 2011 in “Dermatologic Clinics”

Hair loss in autoimmune blistering skin diseases varies and may regrow with disease control.

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