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GlossaryDesmosomes

specialized cell structures that glue adjacent cells together

Desmosomes are specialized structures in the cell membrane that act like glue, holding cells together, particularly in tissues that experience a lot of stress, such as skin and heart muscle. They are composed of proteins that link the cytoskeletons of adjacent cells, providing mechanical strength and stability to tissues.

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research Immunolocalization of Junctional Proteins in Human Hairs Indicates That the Membrane Complex Stabilizes the Inner Root Sheath While Desmosomes Contact the Companion Layer Through Specific Keratins

12 citations , January 2013 in “Acta Histochemica”

Junctional proteins stabilize the inner root sheath and connect the companion layer in human hair.

research Desmosomes in Developing Human Epidermis

11 citations , January 2010 in “Dermatology Research and Practice”

Desmosomes are crucial for human skin development, increasing in density as the skin matures.

research Using the Frog Epidermis to Uncover Desmosome Function and Regulation in the Developing Embryo

January 2018 in “VCU Scholars Compass (Virginia Commonwealth University)”

Desmosomes are crucial for skin and heart development, and JNK may help regulate them.

research Ichthyosis Follicularis with Alopecia and Photophobia in a Mother and Daughter

36 citations , January 2000 in “British journal of dermatology/British journal of dermatology, Supplement”

A mother and daughter had severe skin, hair, and eye issues linked to IFAP.

research Histopathological and Ultrastructural Study of Ectodermal Dysplasia/Skin Fragility Syndrome

31 citations , August 2005 in “The American Journal of Dermatopathology”

The study concluded that PKP1 is essential for skin integrity and hair growth, and its dysfunction causes the symptoms of ectodermal dysplasia/skin fragility syndrome.

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