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GlossaryDesmosomes

specialized cell structures that glue adjacent cells together

Desmosomes are specialized structures in the cell membrane that act like glue, holding cells together, particularly in tissues that experience a lot of stress, such as skin and heart muscle. They are composed of proteins that link the cytoskeletons of adjacent cells, providing mechanical strength and stability to tissues.

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research Immunolocalization of Junctional Proteins in Human Hairs Indicates That the Membrane Complex Stabilizes the Inner Root Sheath While Desmosomes Contact the Companion Layer Through Specific Keratins

12 citations , January 2013 in “Acta Histochemica”

Junctional proteins stabilize the inner root sheath and connect the companion layer in human hair.

research Ichthyosis Follicularis with Alopecia and Photophobia in a Mother and Daughter

36 citations , January 2000 in “British journal of dermatology/British journal of dermatology, Supplement”

A mother and daughter had severe skin, hair, and eye issues linked to IFAP.

research Histopathological and Ultrastructural Study of Ectodermal Dysplasia/Skin Fragility Syndrome

31 citations , August 2005 in “The American Journal of Dermatopathology”

The study concluded that PKP1 is essential for skin integrity and hair growth, and its dysfunction causes the symptoms of ectodermal dysplasia/skin fragility syndrome.

research Deficient Plakophilin-1 Expression Due to a Mutation in PKP1 Causes Ectodermal Dysplasia-Skin Fragility Syndrome in Chesapeake Bay Retriever Dogs

28 citations , February 2012 in “PLoS ONE”

A PKP1 gene mutation causes skin fragility and hair loss in Chesapeake Bay retriever puppies.

research A Case of Monilethrix Caused by Novel Compound Heterozygous Mutations in the Desmoglein 4 (DSG4) Gene

26 citations , April 2011 in “British Journal of Dermatology”

New mutations in the DSG4 gene cause a rare hair condition.

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