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    Glossary Desmosomes

    specialized cell structures that glue adjacent cells together

    Desmosomes are specialized structures in the cell membrane that act like glue, holding cells together, particularly in tissues that experience a lot of stress, such as skin and heart muscle. They are composed of proteins that link the cytoskeletons of adjacent cells, providing mechanical strength and stability to tissues.

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    Research 30 of 542

    1. Corneodesmosin gene ablation induces lethal skin-barrier disruption and hair-follicle degeneration related to desmosome dysfunction Journal of Cell Science · 2009 · 87 citations
    2. Immunolocalization of junctional proteins in human hairs indicates that the membrane complex stabilizes the inner root sheath while desmosomes contact the companion layer through specific keratins Acta Histochemica · 2013 · 12 citations
    3. Desmosomes in Developing Human Epidermis Dermatology Research and Practice · 2010 · 11 citations
    4. A desmosomal cadherin controls multipotent hair follicle stem cell quiescence and orchestrates regeneration through adhesion signaling iScience · 2023 · 1 citations
    5. LB1076 Using the frog embryonic epidermis as a model to study desmosome function during development Journal of Investigative Dermatology · 2019
    6. USING THE FROG EPIDERMIS TO UNCOVER DESMOSOME FUNCTION AND REGULATION IN THE DEVELOPING EMBRYO VCU Scholars Compass (Virginia Commonwealth University) · 2018
    7. 876 Imaging nanoscale changes in desmosome protein organization Journal of Investigative Dermatology · 2018
    8. 441 RPGRIP1L facilitates desmosomal adhesion through suppressing PKCβII-mediated desmoglein endocytosis: Implication in pemphigus 2016
    9. 1422 Uncoupling desmosomal cadherin adhesion activates quiescent hair follicle stem cells and orchestrates self-organized regeneration through outside-in signaling Journal of Investigative Dermatology · 2023
    10. Patterns of desmocollin synthesis in human epithelia: immunolocalization of desmocollins 1 and 3 in special epithelia and in cultured cells. PubMed · 1996 · 96 citations
    11. Increased expression of keratin 16 causes anomalies in cytoarchitecture and keratinization in transgenic mouse skin. The Journal of Cell Biology · 1994 · 94 citations
    12. Biology and Genetics of Hair Annual Review of Genomics and Human Genetics · 2010 · 89 citations
    13. Loose Anagen Hair as a Cause of Hereditary Hair Loss in Children Archives of Dermatology · 1992 · 55 citations
    14. Ultrastructural Resemblance of Basal Cell Epithelioma to Primary Epithelial Germ Journal of Cutaneous Pathology · 1978 · 47 citations
    15. Congenital hair loss disorders: Rare, but not too rare The Journal of Dermatology · 2011 · 41 citations
    16. Against the Rules: Human Keratin K80 Journal of Biological Chemistry · 2010 · 40 citations
    17. Ichthyosis follicularis with alopecia and photophobia in a mother and daughter 2000 · 36 citations
    18. Histopathological and Ultrastructural Study of Ectodermal Dysplasia/Skin Fragility Syndrome The American Journal of Dermatopathology · 2005 · 31 citations
    19. Deficient Plakophilin-1 Expression Due to a Mutation in PKP1 Causes Ectodermal Dysplasia-Skin Fragility Syndrome in Chesapeake Bay Retriever Dogs PLoS ONE · 2012 · 28 citations
    20. Growth of human hair follicle keratinocytes in vitro Journal of the American Academy of Dermatology · 1987 · 28 citations
    21. A case of monilethrix caused by novel compound heterozygous mutations in the desmoglein 4 (DSG4) gene British Journal of Dermatology · 2011 · 26 citations
    22. Regulation of Hair Shedding by the Type 3 IP3 Receptor 2012 · 19 citations
    23. Structural and biochemical changes underlying a keratoderma-like phenotype in mice lacking suprabasal AP1 transcription factor function Cell Death and Disease · 2015 · 17 citations
    24. Desmoglein 4 Mutations Underlie Localized Autosomal Recessive Hypotrichosis in Humans, Mice, and Rats Journal of Investigative Dermatology Symposium Proceedings · 2005 · 13 citations
    25. Bikunin, a Serine Protease Inhibitor, is Present on the Cell Boundary of Epidermis Journal of Investigative Dermatology · 1999 · 13 citations
    26. Hair Loss in Autoimmune Cutaneous Bullous Disorders Dermatologic Clinics · 2011 · 12 citations
    27. A Spontaneous Deletion within the Desmoglein 3 Extracellular Domain of Mice Results in Hypomorphic Protein Expression, Immunodeficiency, and a Wasting Disease Phenotype ˜The œAmerican journal of pathology · 2014 · 11 citations
    28. Molecular Genetics of Alopecias Current problems in dermatology · 2015 · 9 citations
    29. Homozygous Nonsense Mutation in DSC3 Resulting in Skin Fragility and Hypotrichosis 2020 · 8 citations
    30. Hereditary mucoepithelial dysplasia: unique histopathological findings in skin lesions Journal of cutaneous pathology · 2012 · 7 citations