Molecular Genetics of Alopecias

January 2015 in “ Current problems in dermatology ”

Yuval Ramot, Abraham Zlotogorski

TLDR Scientists have found specific genes linked to different hair loss conditions, which could lead to new treatments.

The 2015 document summarizes the progress in understanding the genetic basis of various alopecias, including monogenic and polygenic disorders. It identifies specific gene mutations responsible for hair diseases, such as mutations in LPAR6, LIPH, keratin genes, desmosomal components, and the HR gene, which affect hair growth, structure, and integrity. The paper also discusses the genetic factors in androgenetic alopecia (AGA), with 12 susceptibility loci identified, and alopecia areata (AA), with several loci identified through GWAS studies. It emphasizes the role of WNT signaling and the immune system in these conditions. The findings suggest that a deeper understanding of the molecular pathways can lead to new treatments for hair disorders.

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20 / 20 results

research Investigation of Four Novel Male Androgenetic Alopecia Susceptibility Loci: No Association with Female Pattern Hair Loss

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research Male-Pattern Baldness Susceptibility Locus at 20p11

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research Disruption of P2RY5, an Orphan G Protein–Coupled Receptor, Underlies Autosomal Recessive Woolly Hair

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research WNT Signaling in the Control of Hair Growth and Structure

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2 / 2 results

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August 2015 in “Europe PMC (PubMed Central)”

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