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Glossary Hair Integrity

overall health and strength of hair strands

Hair integrity refers to the overall health and strength of hair, encompassing its structure, moisture content, and resilience to damage. For professionals, it involves assessing factors like the cuticle layer's condition, protein content, and the hair's ability to withstand chemical treatments and physical stress without breaking or becoming excessively dry.

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Research

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research 259 Scalp hair follicle dermal sheath fibroblasts express genes associated with promotion of skin integrity/wound healing and prevention of autoimmune responses in Recessive Dystrophic Epidermolysis Bullosa

November 2024 in “Journal of Investigative Dermatology”

Scalp hair follicle cells help protect and heal skin in certain skin conditions.

research Responses of hair follicle gene expression to the cold season and growth promotion technology in Angus and Brahman cattle

June 2026 in “Domestic Animal Endocrinology”

This study found that hair follicle gene expression varies between Angus and Brahman cattle and responds to growth-promoting treatments, which may reflect breed differences in adaptability to cold stress.

research Comparative Transcriptome Analysis of Fetal Skin Reveals Key Genes Related to Hair Follicle Morphogenesis in Cashmere Goats

127 citations , March 2016 in “PLoS ONE”

This study found that transcriptome profiling of cashmere goat skin revealed key genes and pathways involved in hair follicle initiation, differentiation, and maturation, which are critical for improving fleece production.

research Corneodesmosin gene ablation induces lethal skin-barrier disruption and hair-follicle degeneration related to desmosome dysfunction

87 citations , July 2009 in “Journal of Cell Science”

The researchers found that corneodesmosin is crucial for maintaining skin barrier integrity and hair follicle architecture in mice, with its deletion leading to severe skin and hair abnormalities.

research 301 Whole exome sequencing in AA patients identifies a hotspot mutation in the type II hair keratin gene, KRT82

June 2020 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study found that rare damaging variants in the KRT82 gene, which affect hair shaft integrity, may contribute to the risk of alopecia areata.

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Community Join

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community New study suggests hair regrowth on wounded and bald skin may be possible

4 upvotes 7 years ago

Hair regrowth on wounded and bald skin may be possible by activating the sonic hedgehog gene, leading to hair regrowth in mice. The findings are promising but may not directly apply to humans.

community Creatine & Hair Loss — My Personal Experience (And a Bit of Simple Math)

71 upvotes 1 year ago

Creatine may accelerate hair loss in those genetically predisposed, with some users reporting increased shedding while taking it and improvement after stopping. Some users use treatments like finasteride and minoxidil, while opinions on creatine's impact vary.

community Does high sugar/insulin resistance or generally bad diet prevent fin/dut from working?

10 upvotes 9 months ago

A poor diet high in sugar and insulin resistance may reduce the effectiveness of finasteride in treating hair loss. Improving diet could potentially enhance treatment results.

community Need Help Please! It's about Exosome therapy and my hair fall. If you have any questions, feel free to ask!

in Treatment 1 upvotes 6 months ago

A person experienced hair loss due to stress, hormonal changes, and possibly genetics, and tried treatments like minoxidil, finasteride, and dutasteride. They are now considering exosome therapy but are unsure about its effectiveness and which dermatologist to trust.

community How long does it take after an environmental / lifestyle change for hair loss to actually slow down?

5 upvotes 10 months ago

Lifestyle changes may not significantly impact hair loss, as factors like DHT and genetics play a larger role. Some users suggest treatments like finasteride, dutasteride, and microneedling for hair growth.

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