Androgenetic Alopecia: Identification Of Four Genetic Risk Loci And Evidence For The Contribution Of WNT Signaling To Its Etiology

    Stefanie Heilmann, Amy K. Kiefer, Nadine Fricker, Dmitriy Drichel, Axel M. Hillmer, Christine Herold, Joyce Y. Tung, Nicholas Eriksson, Silke Redler, Regina C. Betz, Rui Li, Ari Karason, Dale R. Nyholt, Kijoung Song, Sita H. Vermeulen, Stavroula Kanoni, George Dedoussis, Nicholas G. Martin, Lambertus A. Kiemeney, Vincent Mooser, Kari Stefansson, J. Brent Richards, Tim Becker, Felix F. Brockschmidt, David A. Hinds, Markus M. Nöthen
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    TLDR Four genetic risk spots found for hair loss, with WNT signaling involved and a link to curly hair.
    This study identified four genetic risk loci for androgenetic alopecia (AGA) and provided evidence for the contribution of WNT signaling to its etiology. The strongest association was observed for rs7349332 on chr2q35, located intronically in WNT10A. The study also found an unexpected link between AGA and curly hair, which may specifically involve the WNT signaling pathway. The researchers suggest that these findings provide insight into the genetic basis of AGA and suggest potential therapeutic targets.
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