Evaluation of the Predictive Capacity of DNA Variants Associated with Straight Hair in Europeans

    September 2015 in “ Forensic Science International: Genetics ”
    Ewelina Pośpiech, Joanna Karłowska-Pik, Magdalena Marcińska, Sarah Abidi, Jeppe Dyrberg Andersen, M. van den Berge, Ángel Carracedo, Mayra Eduardoff, Ana Freire-Aradas, Niels Morling, Titia Sijen, Małgorzata Skowron, Jens Söchtig, Denise Syndercombe‐Court, Natalie Weiler, Peter M. Schneider, David J. Ballard, Claus Børsting, Walther Parson, C. Phillips, Wojciech Branicki
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    TLDR Certain DNA variants can predict straight hair in Europeans but are not highly specific.
    The study investigated the association of six single nucleotide polymorphisms (SNPs) with hair morphology in a Polish sample of 528 individuals and an independent test set of 142 males from six European populations. It confirmed the association of SNPs rs11803731 (TCHH), rs7349332 (WNT10A), and rs1268789 (FRAS1) with straight hair, which explained about 8.2% of the variance in hair morphology. The best predictive results were obtained using neural networks, which showed high sensitivity but low specificity. The TTGGGG genotype was the best predictor for straight hair. Additionally, a suggestive association was found between hair morphology and SNP rs4679955, which is also associated with male pattern baldness. The study concluded that while the identified SNPs are sensitive predictors of straight hair, they lack specificity, and further research is needed to improve the predictive accuracy for hair morphology.
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