TLDR Certain genetic variations in the RAB5B gene are linked to a higher risk of polycystic ovary syndrome in Chinese Han women.
In 2019, a study involving 1024 Chinese Han women, 512 with polycystic ovary syndrome (PCOS) and 512 controls, found a significant association between single nucleotide polymorphisms (SNPs) in the RAB5B gene and PCOS. Specifically, the risk of PCOS was significantly higher in carriers of certain alleles of the RAB5B gene, with the risk being 3.91 times higher for C allele carriers of the rs1045435 locus, 4.09 times higher for G allele carriers of the rs11550558 locus, 1.66 times higher for C allele carriers of the rs705700 locus, and 3.84 times higher for A allele carriers of the rs11171718 locus. The study also found that plasma levels of miR-24 and miR-320 were significantly different in PCOS patients compared to controls, and these levels were associated with certain SNPs. The study concluded that these SNPs in the RAB5B gene and their interaction with age and BMI could be associated with the risk of PCOS in Chinese Han women.
29 citations,
February 2018 in “Genetics research international” Certain genetic variations are linked to increased androgen levels in PCOS, but more research is needed to understand these connections fully.
50 citations,
January 2016 in “The Journal of Clinical Endocrinology and Metabolism” Certain microRNAs in the fluid around eggs are linked to Polycystic Ovary Syndrome and may help diagnose it.
222 citations,
January 2014 in “International journal of reproductive medicine” Insulin resistance and obesity are key factors in the development and worsening of polycystic ovary syndrome, and lifestyle changes are important for managing it.
21 citations,
February 2016 in “Reproductive Biomedicine Online” The conclusion suggests that PCOS may persist due to genetic traits that, while harmful for female fertility, could have provided survival and reproductive benefits to males.
47 citations,
August 2014 in “The Journal of Clinical Endocrinology and Metabolism” The research suggests that the global distribution of PCOS is likely due to historical human migration and that genes affecting PCOS may have different impacts on males and females.
29 citations,
February 2018 in “Genetics research international” Certain genetic variations are linked to increased androgen levels in PCOS, but more research is needed to understand these connections fully.
PCOS has a strong genetic basis, but more research is needed to fully understand it.
18 citations,
April 2016 in “Endocrinology and Metabolism Clinics of North America” The document concludes that diagnosing PCOS in teenagers is difficult and should focus on specific hormone levels and menstrual irregularities, while also considering treatment for symptoms and related health issues.
