Association of Single Nucleotide Polymorphisms in the RAB5B Gene 3′UTR Region with Polycystic Ovary Syndrome in Chinese Han Women

In 2019, a study involving 1024 Chinese Han women, 512 with polycystic ovary syndrome (PCOS) and 512 controls, found a significant association between single nucleotide polymorphisms (SNPs) in the RAB5B gene and PCOS. Specifically, the risk of PCOS was significantly higher in carriers of certain alleles of the RAB5B gene, with the risk being 3.91 times higher for C allele carriers of the rs1045435 locus, 4.09 times higher for G allele carriers of the rs11550558 locus, 1.66 times higher for C allele carriers of the rs705700 locus, and 3.84 times higher for A allele carriers of the rs11171718 locus. The study also found that plasma levels of miR-24 and miR-320 were significantly different in PCOS patients compared to controls, and these levels were associated with certain SNPs. The study concluded that these SNPs in the RAB5B gene and their interaction with age and BMI could be associated with the risk of PCOS in Chinese Han women.