Association of Single Nucleotide Polymorphisms in the RAB5B Gene 3′UTR Region with Polycystic Ovary Syndrome in Chinese Han Women

    April 2019 in “ Bioscience Reports ”
    Yu J, Caifei Ding, Siqi Guan, Chenye Wang
    Image of study
    TLDR Certain genetic variations in the RAB5B gene are linked to a higher risk of polycystic ovary syndrome in Chinese Han women.
    In 2019, a study involving 1024 Chinese Han women, 512 with polycystic ovary syndrome (PCOS) and 512 controls, found a significant association between single nucleotide polymorphisms (SNPs) in the RAB5B gene and PCOS. Specifically, the risk of PCOS was significantly higher in carriers of certain alleles of the RAB5B gene, with the risk being 3.91 times higher for C allele carriers of the rs1045435 locus, 4.09 times higher for G allele carriers of the rs11550558 locus, 1.66 times higher for C allele carriers of the rs705700 locus, and 3.84 times higher for A allele carriers of the rs11171718 locus. The study also found that plasma levels of miR-24 and miR-320 were significantly different in PCOS patients compared to controls, and these levels were associated with certain SNPs. The study concluded that these SNPs in the RAB5B gene and their interaction with age and BMI could be associated with the risk of PCOS in Chinese Han women.
    Discuss this study in the Community →

    Research cited in this study

    3 / 3 results

    Related Community Posts Join

    6 / 19 results

      community PCOS Hair Loss: What’s Helped Me (and What Didn’t)

      in Treatment  11 upvotes 1 week ago
      OP shares their experience with PCOS-related hair loss, highlighting that addressing vitamin D and ferritin deficiencies, managing hormones with spironolactone, and using gentle hair care products helped improve their condition. They advise against relying on "miracle" hair oils and emphasize the importance of medical evaluation and a combined approach to treatment.

      community How does hair loss and recovery work?

      in Chat  12 upvotes 1 year ago
      Hair loss varies due to genetic sensitivity to DHT and other factors. Treatments discussed include finasteride, minoxidil, RU58841, and microneedling.

      community Sugar and Hair loss connections

      in Research/Science  41 upvotes 3 months ago
      High sugar diets may worsen hair loss by increasing 5α-reductase activity and androgen levels, especially in women with PCOS. A low sugar diet might reduce scalp DHT levels, similar to finasteride, but genetics also significantly influence hair loss.

      community C’est terrible - at my wits end

      in Female  450 upvotes 1 year ago
      A 29-year-old woman is experiencing gradual hair thinning since age 15, suspects Androgenic Alopecia, and has tried 5% minoxidil with little success. She has purchased various hair loss treatments including minoxidil, dutasteride, finasteride, and spironolactone, but is cautious about starting them due to potential interactions with her ADHD medication.

    Similar Research

    5 / 1000+ results