TLDR Certain microRNAs in the fluid around eggs are linked to Polycystic Ovary Syndrome and may help diagnose it.
The study examined the expression of microRNAs (miRNAs) in the follicular fluid of 49 women with Polycystic Ovary Syndrome (PCOS) and 21 healthy controls, all undergoing in vitro fertilization (IVF). It found that certain miRNAs, specifically miR-24-3p, -29a, -151-3p, and -574-3p, were down-regulated in PCOS patients compared to controls. Additionally, miR-518f-3p was up-regulated in hyper-androgenic PCOS patients and correlated with testosterone levels. The study concluded that these miRNAs are associated with PCOS and could serve as potential biomarkers for the condition, with miR-151-3p showing high diagnostic value. The findings suggest that an altered miRNA profile may contribute to the heterogeneous nature of PCOS and could help in patient stratification.
1540 citations,
October 2008 in “Fertility and Sterility” The report concludes that PCOS is mainly a condition of excess male hormones and its definition may change as new information is discovered.
1744 citations,
August 2006 in “The Journal of Clinical Endocrinology and Metabolism” Polycystic Ovary Syndrome should be seen mainly as a condition of excess male hormones, with a focus on this in its definition.
491 citations,
July 2000 in “The Journal of Clinical Endocrinology and Metabolism” Polycystic ovary syndrome is found in 6.5% of unselected Caucasian women in Spain.
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January 2023 in “International journal of molecular sciences” Certain miRNAs play a key role in the growth of cashmere by affecting hair follicle development and regeneration.
22 citations,
April 2017 in “Journal of Investigative Dermatology” Non-coding RNAs are crucial for skin development and health.
August 2023 in “Research Square (Research Square)” Two microRNAs affect hair follicle development in sheep by targeting specific genes.
17 citations,
May 2018 in “BMC genomics” Researchers found genes and microRNAs that control curly fleece in Chinese Tan sheep.
12 citations,
October 2021 in “Cells” Targeting a protein that blocks hair growth with microRNAs could lead to new hair loss treatments, but more research is needed.
