MiR-23b and MiR-133 Cotarget TGFβ2/NOTCH1 in Dermal Fibroblasts and Affect Hair Follicle Development in Sheep

    August 2023 in “ Research Square (Research Square) ”
    Junlin He, Wei Chen, Xixia Huang, Guoping Zhang, Jingyi Mao, Xue Li, Chengwei Yang, Wenjing Zhang, Kechuan Tian, Guifen Liu
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    TLDR Two microRNAs affect hair follicle development in sheep by targeting specific genes.
    The study investigates the role of two microRNAs, oar-miR-23b and oar-miR-133, in the development of hair follicles (HFs) in superfine wool sheep. These microRNAs target the genes TGFβ2 and NOTCH1, which are expressed by sheep dermal fibroblasts (SDFs). The overexpression or inhibition of these microRNAs was found to inhibit the proliferation and migration of SDFs and promote their apoptosis, thereby affecting HF development. The research highlights the involvement of the TGF-β, Hippo, and WNT signaling pathways in this process. The findings provide molecular markers that could guide the breeding of ultrafine wool sheep.
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