MiR-23b and MiR-133 Cotarget TGFβ2/NOTCH1 in Dermal Fibroblasts and Affect Hair Follicle Development in Sheep

    Junlin He, Wei Chen, Xixia Huang, Guoping Zhang, Jingyi Mao, Xue Li, Chengwei Yang, Wenjing Zhang, Kechuan Tian, Guifen Liu
    Image of study
    TLDR Two microRNAs affect hair follicle development in sheep by targeting specific genes.
    The study investigates the role of two microRNAs, oar-miR-23b and oar-miR-133, in the development of hair follicles (HFs) in superfine wool sheep. These microRNAs target the genes TGFβ2 and NOTCH1, which are expressed by sheep dermal fibroblasts (SDFs). The overexpression or inhibition of these microRNAs was found to inhibit the proliferation and migration of SDFs and promote their apoptosis, thereby affecting HF development. The research highlights the involvement of the TGF-β, Hippo, and WNT signaling pathways in this process. The findings provide molecular markers that could guide the breeding of ultrafine wool sheep.
    Discuss this study in the Community →

    Research cited in this study

    20 / 20 results

    Related Community Posts Join

    6 / 23 results

      community Getting dutasteride in germany

      in Finasteride/Dutasteride  18 upvotes 4 months ago
      You can get dutasteride in Germany through the Teleclinic app, which sends a prescription to a nearby pharmacy. It costs around 18-19 euros for the prescription and 47 euros for 90 pills of Avodart 0.5.

      community Anyone Try Microneedling with Exosomes/AAPE?

      in Microneedling  2 upvotes 2 years ago
      User asks where to purchase exosomes/AAPE for microneedling hair loss treatment. Links to research on hair regeneration therapy, stem cell therapy, exosome therapy, and dermal exosomes provided.

      community Megadosing Koshine826(Pyrilutamide), my Plan.

      in Treatment  1 upvotes 2 months ago
      The user plans to use 1% Koshine826, 0.1% Alfatradiol, Minoxidil with Tretinoin, microneedling, and Stemoxydine for hair loss treatment. They expect significant recovery with this regimen.

      community Help in Germany to get recommended medicine

      in Finasteride/Dutasteride  5 upvotes 3 months ago
      A user in Germany is seeking advice on obtaining Dutasteride, Minoxidil, and Biotin for hair treatment before a hair transplant. They face difficulties getting prescriptions and are concerned about delays due to required exams.

    Related Research

    3 / 3 results