Alteration of Skin Properties with Autologous Dermal Fibroblasts

May 2014 in “ International Journal of Molecular Sciences ”

Rajesh L. Thangapazham, Thomas N. Darling, Jon H Meyerle

TLDR Using your own skin cells can help repair aging skin and promote hair growth.

The document from 9 years ago discussed the use of autologous dermal fibroblasts in skin repair and hair growth. It referenced a double-blind, placebo-controlled clinical trial and other studies that utilized skin-derived fibroblasts for various treatments. The document also highlighted the use of autologous fibroblast culture in repairing aging skin. Regarding hair growth, it cited a study where hair growth was induced by implanting cultured dermal papilla cells and another study that explored the potential of these cells in hair regeneration. Additionally, it mentioned a phase 1/2a clinical trial using autologous dermal sheath cup cell injections to treat androgenetic alopecia in men and women, reporting 12-month interim safety results.

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research Does Prostaglandin D2 Hold the Cure to Male Pattern Baldness?

57 citations , March 2014 in “Experimental Dermatology”

Prostaglandin D₂ might be targeted for new male pattern baldness treatments.

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51 citations , February 2014 in “Journal of Investigative Dermatology”

Human skin cells can create new hair follicles when transplanted into mice.

research Regionalization of the Skin

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Skin varies in thickness, color, and features due to complex genetic and cellular processes.

research Microenvironmental Reprogramming by Three-Dimensional Culture Enables Dermal Papilla Cells to Induce De Novo Human Hair-Follicle Growth

256 citations , October 2013 in “Proceedings of the National Academy of Sciences of the United States of America”

Growing human skin cells in a 3D environment can stimulate new hair growth.

research Hair Follicle Signaling Networks: A Dermal Papilla–Centric Approach

28 citations , October 2013 in “Journal of Investigative Dermatology”

The document concludes that dermal papilla cells are key for hair growth and could be used in new hair loss treatments.

research Concise Review: Tissue-Engineered Skin and Nerve Regeneration in Burn Treatment

84 citations , June 2013 in “Stem Cells Translational Medicine”

New methods for skin and nerve regeneration can improve healing and feeling after burns.

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32 citations , July 2012 in “Stem Cells Translational Medicine”

Vitamin D3 can help improve hair growth by enhancing the function of specific skin cells and could be useful in hair regeneration treatments.

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85 citations , April 2012 in “PLOS ONE”

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59 citations , April 2012 in “Journal of Dermatological Science”

Environmental factors at different levels control hair stem cell activity, which could lead to new hair growth and alopecia treatments.

research Sphere Formation Increases the Ability of Cultured Human Dermal Papilla Cells to Induce Hair Follicles from Mouse Epidermal Cells in a Reconstitution Assay

75 citations , January 2012 in “Journal of Investigative Dermatology”

Forming spheres boosts the ability of certain human cells to create hair follicles when mixed with mouse skin cells.

research Review of Hair Follicle Dermal Cells

321 citations , January 2010 in “Journal of Dermatological Science”

Dermal cells are key in controlling hair growth and could potentially be used in hair loss treatments, but more research is needed to improve hair regeneration methods.

research Hair Follicle Neogenesis Induced by Cultured Human Scalp Dermal Papilla Cells

63 citations , September 2009 in “Regenerative Medicine”

Scientists found a way to grow human hair cells in a lab that can create new hair when transplanted.

research Medical Treatments for Male and Female Pattern Hair Loss

212 citations , October 2008 in “Journal of The American Academy of Dermatology”

Minoxidil and finasteride treat hair loss in men, while minoxidil treats hair loss in women.

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205 citations , May 2005 in “Journal of Investigative Dermatology”

Scientists have found a way to create hair follicles from skin cells of newborn mice, which can grow and cycle naturally when injected into adult mouse skin.

research Cultured Peribulbar Dermal Sheath Cells Can Induce Hair Follicle Development and Contribute to the Dermal Sheath and Dermal Papilla

208 citations , December 2003 in “Journal of Investigative Dermatology”

Certain cells from hair follicles can create new hair and contribute to hair growth when implanted in mice.

research Molecular Biology of Hair Morphogenesis: Development and Cycling

155 citations , August 2003 in “Journal Of Experimental Zoology Part B: Molecular And Developmental Evolution”

Understanding hair growth involves complex interactions between molecules and could help treat hair disorders.

research Regulation of Keratin 9 in Nonpalmoplantar Keratinocytes by Palmoplantar Fibroblasts Through Epithelial-Mesenchymal Interactions

92 citations , April 1999 in “The journal of investigative dermatology/Journal of investigative dermatology”

Nonpalmoplantar skin cells can be made to express keratin 9 by interacting with palmoplantar fibroblasts.

1 / 1 results

research Wound Healing and Skin Regeneration

359 citations , January 2015 in “Cold Spring Harbor Perspectives in Medicine”

Hair growth phase and certain genes can speed up wound healing, while an inflammatory mediator can slow down new hair growth after a wound. Understanding these factors can improve tissue regeneration during wound healing.