Does Prostaglandin D2 Hold the Cure to Male Pattern Baldness?

    February 2014 in “ Experimental Dermatology ”
    Ashley Nieves, Luis A. Garza
    Studysummary This review discusses the role of Prostaglandin D2 and its synthase in androgenetic alopecia but reports no new clinical findings, suggesting pathways for future therapeutic development.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 23

    1. A Prostaglandin D-Synthase-Positive Mast Cell Gradient Characterizes Scalp Patterning Journal of Cutaneous Pathology · 2013
    2. No Genetic Support for a Contribution of Prostaglandins to the Etiology of Androgenetic Alopecia British Journal of Dermatology · 2013
    3. The Biodisposition and Hypertrichotic Effects of Bimatoprost in Mouse Skin Experimental dermatology · 2013
    4. Prostaglandin D2 Inhibits Wound-Induced Hair Follicle Neogenesis Through the Receptor Gpr44 Journal of Investigative Dermatology · 2012
    5. The Prostamide-Related Glaucoma Therapy, Bimatoprost, Offers a Novel Approach for Treating Scalp Alopecias The FASEB Journal · 2012
    6. Androgen Actions on the Human Hair Follicle: Perspectives Experimental Dermatology · 2012
    7. Prostaglandin D2 Inhibits Hair Growth and Is Elevated in Bald Scalp of Men with Androgenetic Alopecia Science Translational Medicine · 2012
    8. Bald Scalp in Men with Androgenetic Alopecia Retains Hair Follicle Stem Cells but Lacks CD200-Rich and CD34-Positive Hair Follicle Progenitor Cells Journal of Clinical Investigation · 2011
    9. Expression of NAD+-Dependent 15-Hydroxyprostaglandin Dehydrogenase and Protection of Prostaglandins in Human Hair Follicle Experimental Dermatology · 2008
    10. Prostanoid Receptors in Anagen Human Hair Follicles Experimental dermatology · 2007
    11. Prostaglandin Metabolism in Human Hair Follicle Experimental Dermatology · 2007
    12. Influence of Prostaglandin F2α and Its Analogues on Hair Regrowth and Follicular Melanogenesis in a Murine Model Experimental dermatology · 2005
    13. Androgen Regulation of the Human Hair Follicle: The Type I Hair Keratin hHa7 Is a Direct Target Gene in Trichocytes Journal of Investigative Dermatology · 2004
    14. Minoxidil: Mechanisms of Action on Hair Growth British Journal of Dermatology · 2004
    15. Expression of Cyclooxygenase Isozymes During Morphogenesis and Cycling of Pelage Hair Follicles in Mouse Skin: Precocious Onset of the First Catagen Phase and Alopecia Upon Cyclooxygenase-2 Overexpression Journal of Investigative Dermatology · 2003
    16. Prostaglandin-Induced Hair Growth Survey of Ophthalmology · 2002
    17. Molecular Mechanisms Regulating Hair Follicle Development ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2002
    18. Asebia-2J (Scd1ab2J): A New Allele and a Model for Scarring Alopecia ˜The œAmerican journal of pathology · 2000
    19. Treatment of Hair Loss The New England Journal of Medicine · 1999
    20. The Biology of Hair Follicles The New England Journal of Medicine · 1999
    21. Activation of Cytoprotective Prostaglandin Synthase-1 by Minoxidil as a Possible Explanation for Its Hair Growth-Stimulating Effect Journal of Investigative Dermatology · 1997
    22. Selective Inhibition by Minoxidil of Prostacyclin Production by Cells in Culture Biochemical Pharmacology · 1988
    23. Human Essential Fatty Acid Deficiency Archives of Dermatology · 1977

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    6. Effectiveness of the Treatment Plan for Androgenetic Alopecia PubMed · 2007
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    8. Nonscarring Hair Loss Disorders Postgraduate Medicine · 1982