Does Prostaglandin D2 Hold the Cure to Male Pattern Baldness?

    February 2014 in “ Experimental Dermatology ”
    Ashley Nieves, Luis A. Garza
    Image of study
    TLDR Prostaglandin D₂ might be targeted for new male pattern baldness treatments.
    The document from 2014 explores the connection between Prostaglandin D₂ (PGD₂) and androgenetic alopecia (AGA), or male pattern baldness, noting that PGD₂ levels are higher in the balding areas of men with AGA and can inhibit hair growth. It identifies the enzyme prostaglandin D₂ synthase (PTGDS) and its receptor GPR44 as key components in this process and suggests that targeting these could lead to new treatments for AGA. The paper calls for further research to confirm the role of PGD₂ in hair loss, including studies on its effects throughout the hair cycle, its involvement in other types of hair loss, and the potential for reversing hair miniaturization by inhibiting PGD₂ or GPR44. The research was supported by NIAMS/NIH grant R01AR064297 and involved input from experts in the field, with no conflicts of interest declared by the authors.
    Discuss this study in the Community →

    Research cited in this study

    20 / 20 results

    Related Community Posts Join

    6 / 60 results

      community How I started reversing Male Pattern Baldness naturally ?

      in Question  6 upvotes 7 years ago
      The user reversed male pattern baldness using a pro-thyroid diet, lifestyle changes, and scalp stimulation exercises, without Minoxidil or Finasteride. They reported reduced dandruff, itchiness, oiliness, and experienced hair regrowth and thickening over 15 months.
      [object Object]

      community Zyrtec (Cetirizine) antihistamine for hair growth compared to Minoxidil NIH study

      in Minoxidil  35 upvotes 1 year ago
      The conversation discusses the potential of topical cetirizine (Zyrtec) for hair growth in comparison to minoxidil, noting cetirizine's ability to reduce prostaglandin D2, which inhibits hair growth. Users share mixed experiences with cetirizine for allergies and scalp health, and there's a mention of the risk of dementia with long-term antihistamine use.

      community What else is good. Besides the big 3.

      in Chat  34 upvotes 3 months ago
      Key treatments for hair preservation include minoxidil, finasteride/dutasteride, and microneedling, with additional options like specific shampoos, oils, biotin, zinc, tretinoin, clascoterone, and low-level laser therapy. Maintaining a healthy lifestyle, reducing stress, and addressing nutrient deficiencies can also support hair health.

    Related Research

    8 / 8 results