Expression of NAD+-Dependent 15-Hydroxyprostaglandin Dehydrogenase and Protection of Prostaglandins in Human Hair Follicle

March 2008 in “ Experimental Dermatology ”

Jean-François Michelet, Laurent Colombe, Brigitte Gautier, O Gaillard, Florence Benech, Rui Pereira, C. Boulle, Maria Dalko-Csiba, Roger Rozot, Michel Neuwels, Bruno Bernard

NAD+-dependent 15-hydroxyprostaglandin dehydrogenase 15-PGDH prostaglandins melanocytes keratinocytes hair follicle PhCL28A thiazolidine dione derivative compound-1 prostaglandin F2α NAD+-dependent 15-PGDH PGD2 PGF2α

TLDR A substance called compound-1 could help increase hair growth by maintaining prostaglandin levels in hair follicles.

The 2008 study focused on the expression of NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (15-PGDH) in human hair follicles and its potential as a target for hair growth promotion by preserving prostaglandin levels. The enzyme was found to be expressed in melanocytes and keratinocytes within the hair follicle. Through screening over 500 molecules, two compounds were identified that could inhibit 15-PGDH: PhCL28A and a thiazolidine dione derivative, referred to as compound-1. However, only compound-1 was effective in inhibiting 15-PGDH without also decreasing the production of prostaglandin F2α, making it a promising candidate for maintaining prostaglandin levels in the hair follicle and potentially enhancing hair growth. The study did not report the number of human samples used for the investigation.

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15-Deoxy Prostaglandin J2, The Nonenzymatic Metabolite Of Prostaglandin D2, Induces Apoptosis In Keratinocytes Of Human Hair Follicles: A Possible Explanation For Prostaglandin D2-Mediated Inhibition Of Hair Growth

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research Expression of NAD+-Dependent 15-Hydroxyprostaglandin Dehydrogenase and Protection of Prostaglandins in Human Hair Follicle

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A substance called compound-1 could help increase hair growth by maintaining prostaglandin levels in hair follicles.

research Prostaglandin Metabolism in Human Hair Follicle

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Human hair follicles can make and process prostaglandins, which may affect hair growth.

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Research cited in this study

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