Steroidogenic Isoenzymes in Human Hair and Their Potential Role in Androgenetic Alopecia

January 2003 in “ Dermatology ”

Rolf Hoffmann

steroidogenic isoenzymes androgenetic alopecia 5-alpha reductase androgen receptors hair follicles AGA

Studysummary This article provides an overview of recent discoveries about steroidogenic enzymes involved in androgenetic alopecia but reports no new clinical results. Our plain-language summary of this paper — not a Tressless recommendation.

This document from 20 years ago discusses the potential role of steroidogenic isoenzymes in androgenetic alopecia (AGA), a common form of hair loss. The authors review previous research on the genetics and biochemistry of AGA, including the role of 5-alpha reductase and androgen receptors in hair follicles. They also discuss the potential for new treatments targeting these enzymes and receptors. Overall, the authors suggest that a better understanding of the molecular mechanisms underlying AGA could lead to more effective treatments for this condition.

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research An Investigation of Apoptosis in Androgenetic Alopecia

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research Steroid Sulfatase in the Human Hair Follicle Concentrates in the Dermal Papilla

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research Possible Mechanisms of Miniaturization During Androgenetic Alopecia or Pattern Hair Loss

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research Androgen Responsive Genes as They Affect Hair Growth

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In this study, finasteride treatment in men with androgenetic alopecia reduced the expression of caspases in hair follicles to levels similar to those in men with normal scalps.

research Finasteride Is the Main Inhibitor of 5α-Reductase Activity in Microdissected Dermal Papillae of Human Hair Follicles

28 citations , February 1999 in “Archives of Dermatological Research”

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research Androgen-Dependent Beard Dermal Papilla Cells Secrete Autocrine Growth Factors in Response to Testosterone Unlike Scalp Cells

51 citations , November 1998 in “The journal of investigative dermatology/Journal of investigative dermatology”

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research Protease Nexin-1 Is Expressed in Human Dermal Papilla Cells and Is Affected by Androgen

March 1998 in “Journal of dermatological science”

Protease Nexin-1 is found in human hair growth cells and is affected by male hormones.

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research Different Levels of 5α-Reductase Type I and II, Aromatase, and Androgen Receptor in Hair Follicles of Women and Men with Androgenetic Alopecia

416 citations , September 1997 in “Journal of Investigative Dermatology”

People with hair loss have more androgen receptors and enzymes in certain follicles, with men and women showing different patterns.

Inhibition of Hair Growth by Testosterone in the Presence of Dermal Papilla Cells from the Frontal Bald Scalp of the Postpubertal Stumptailed Macaque

research Inhibition of Hair Growth by Testosterone in the Presence of Dermal Papilla Cells from the Frontal Bald Scalp of the Postpubertal Stumptailed Macaque

33 citations , January 1997 in “Endocrinology”

Testosterone was found to inhibit hair follicle epithelial cell proliferation in adult stumptailed macaques only when dermal papilla cells from bald scalps were present, and this effect was reversed by the antiandrogen RU 58841.

research Message of Nexin 1, a Serine Protease Inhibitor, Accumulates in the Follicular Papilla During Anagen of the Hair Cycle

37 citations , December 1995 in “Journal of Cell Science”

This study found that nexin 1 mRNA, a potent protease inhibitor, is prevalent in rat follicular papilla cells and may play a role in regulating hair follicular growth.

research Mechanism of Action of Androgen in Hair Follicles

25 citations , July 1994 in “Journal of dermatological science”

This study observed that testosterone metabolism and androgen receptor localization differ significantly across body sites, with beard hair follicles showing distinct characteristics compared to occipital scalp hair follicles.

research Steroid Chemistry and Hormone Controls During the Hair Follicle Cycle

34 citations , December 1991 in “Annals of the New York Academy of Sciences”

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research In Vitro Effects of Testosterone, Dihydrotestosterone, and Estradiol on Cell Growth of Human Hair Bulb Papilla Cells and Hair Root Sheath Fibroblasts

22 citations , July 1990 in “Acta Dermato Venereologica”

In this study, high concentrations of dihydrotestosterone and testosterone reduced the growth of human hair follicle cells in vitro, while high estradiol levels increased their growth.

research Substrate Specific Sulfatase Activity from Hair Follicles in Recessive X-Linked Ichthyosis

8 citations , September 1987 in “Acta Dermato Venereologica”

In this study, the researchers used structural studies and molecular calculations to suggest that the enzyme in RXLI patient hair follicles is less efficient, rather than completely inactive.

research Serum Elevation of Dehydroepiandrosterone Sulfate Associated with Male Pattern Baldness in Young Men

52 citations , March 1987 in “Journal of the American Academy of Dermatology”

This study found that men with rapidly progressive male pattern baldness had elevated serum dehydroepiandrosterone sulfate levels, suggesting that adrenal hyperactivity may contribute to alopecia in genetically susceptible young men.