Steroidogenic Isoenzymes in Human Hair and Their Potential Role in Androgenetic Alopecia

January 2003 in “ Dermatology ”

Rolf Hoffmann

steroidogenic isoenzymes androgenetic alopecia 5-alpha reductase androgen receptors hair follicles AGA

TLDR Steroidogenic isoenzymes may help improve treatments for common hair loss.

This document from 20 years ago discusses the potential role of steroidogenic isoenzymes in androgenetic alopecia (AGA), a common form of hair loss. The authors review previous research on the genetics and biochemistry of AGA, including the role of 5-alpha reductase and androgen receptors in hair follicles. They also discuss the potential for new treatments targeting these enzymes and receptors. Overall, the authors suggest that a better understanding of the molecular mechanisms underlying AGA could lead to more effective treatments for this condition.

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Research cited in this study

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research Androgenetic Alopecia: Analysis of Proliferation and Apoptosis

12 citations, August 2002 in “Archives of Dermatology”

research An Investigation of Apoptosis in Androgenetic Alopecia

19 citations, June 2002 in “American Journal of Dermatopathology”

Apoptosis contributes to hair loss in androgenetic alopecia.

research Possible Mechanisms of Miniaturization During Androgenetic Alopecia or Pattern Hair Loss

116 citations, September 2001 in “Journal of The American Academy of Dermatology”

Hair loss occurs due to fewer papillary cells, smaller follicles, and shorter growth phases.

research Finasteride Is the Main Inhibitor of 5α-Reductase Activity in Microdissected Dermal Papillae of Human Hair Follicles

28 citations, February 1999 in “Archives of Dermatological Research”

Finasteride potentially treats hair loss by reducing DHT production.

research Androgen-Dependent Beard Dermal Papilla Cells Secrete Autocrine Growth Factors in Response to Testosterone Unlike Scalp Cells

51 citations, November 1998 in “The journal of investigative dermatology/Journal of investigative dermatology”

Beard cells, unlike scalp cells, produce growth factors in response to testosterone, which may explain differences in hair growth.

research Protease Nexin-1 Is Expressed in Human Dermal Papilla Cells and Is Affected by Androgen

March 1998 in “Journal of dermatological science”

Protease Nexin-1 is found in human hair growth cells and is affected by male hormones.

Different Levels of 5α-Reductase Type I and II, Aromatase, and Androgen Receptor in Hair Follicles of Women and Men with Androgenetic Alopecia

research Different Levels of 5α-Reductase Type I and II, Aromatase, and Androgen Receptor in Hair Follicles of Women and Men with Androgenetic Alopecia

416 citations, September 1997 in “Journal of Investigative Dermatology”

People with hair loss have more androgen receptors and enzymes in certain follicles, with men and women showing different patterns.

Inhibition of Hair Growth by Testosterone in the Presence of Dermal Papilla Cells from the Frontal Bald Scalp of the Postpubertal Stumptailed Macaque

research Inhibition of Hair Growth by Testosterone in the Presence of Dermal Papilla Cells from the Frontal Bald Scalp of the Postpubertal Stumptailed Macaque

33 citations, January 1997 in “Endocrinology”

Testosterone can slow down hair growth when combined with certain cells from bald scalps, and this effect can be blocked by an androgen receptor blocker.

research Mechanism of Action of Androgen in Hair Follicles

25 citations, July 1994 in “Journal of dermatological science”

Testosterone affects hair follicles differently across body sites, with beard hair follicles showing more activity of a specific enzyme and presence of androgen receptors compared to scalp hair.

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