Message of Nexin 1, a Serine Protease Inhibitor, Accumulates in the Follicular Papilla During Anagen of the Hair Cycle

    December 1995 in “ Journal of Cell Science ”
    Da-Wen. Yu, Tian Yang, Tadashige Sonoda, Kevin J. Gaffney, Pamela J. Jensen, Thomas P. Dooley, Steve Ledbetter, Irwin M. Freedberg, Robert M. Lavker, Tung‐Tien Sun
    Studysummary This study found that nexin 1 mRNA, a potent protease inhibitor, is prevalent in rat follicular papilla cells and may play a role in regulating hair follicular growth. Our plain-language summary of this paper — not a Tressless recommendation.
    The study identified a 1.3 kb mRNA encoding nexin 1, a serine protease inhibitor, which was found in high quantities in rat follicular papillary cells but not in skin fibroblasts. Nexin 1 can inactivate several growth-modulating serine proteases. In situ hybridization revealed that nexin 1 mRNA accumulated in the follicular papilla cells during the anagen phase of the hair cycle, but was undetectable in keratinocytes or other skin mesenchymal cells. The level of nexin 1 mRNA varied among different rat vibrissa papillary cell lines and correlated with their ability to support follicular reconstitution in vivo. These findings suggested that nexin 1 might play a role in regulating hair follicle growth.
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