Protease-Activated Receptor-1 (Thrombin Receptor) Is Expressed in Mesenchymal Portions of Human Hair Follicle

September 2003 in “ Journal of Investigative Dermatology ”

Tadashi Anan, Tadashige Sonoda, Yuji Asada, Susumu Takayasu, Sotaro Kurata

Protease-Activated Receptor-1 PAR-1 thrombin dermal papilla connective tissue sheath hair follicle hair growth regulation extracellular matrix

TLDR PAR-1 may play a role in hair growth regulation in human hair follicles.

The study examined the expression of Protease-Activated Receptor-1 (PAR-1) in the mesenchymal portions of human hair follicles, particularly in the dermal papilla (DP) and connective tissue sheath, during different hair growth phases. PAR-1 mRNA and protein were detected in these areas, suggesting a potential role in hair growth regulation. Although thrombin, which activates PAR-1, did not significantly stimulate cell proliferation at physiological levels, it was suggested that thrombin might influence hair follicle cycling through PAR-1. The study highlighted the possible involvement of PAR-1 in hair growth by affecting extracellular matrix components and cell viability, but the physiological relevance of thrombin's effects on dermal papilla cells remained uncertain.

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