Proof DHT is not the main cause of hair loss. TRPS1 Gene and Protein might be. PP405 won’t work. AMP-303 might!
    3/10/2026

    From the encyclopedia
    Dutasteride →

    5-alpha reductase inhibitor that blocks both enzyme types, a stronger DHT blocker than finasteride

    PP405 →

    mitochondrial pyruvate carrier (MPC) inhibitor by Pelage in early trials

    At a glance
    In this research discussion post, the primary subjects mentioned are
    💊 Dutasteride (oral) 1.8 years
    💧 PP405 (topical) 8 months
    the tone is 😐 neutral with initial promising results, then no impact.

    Other terms

    Hair loss may be linked to the TRPS1 gene and protein, not just DHT. Amplifica's AMP-303 targets mesenchymal stem cells and shows promise in treating hair loss, unlike Pelage's PP405.
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