Differential Expression Between Human Dermal Papilla Cells from Balding and Non-Balding Scalps Reveals New Candidate Genes for Androgenetic Alopecia

April 2016 in “ Journal of Investigative Dermatology ”

Elaine Chew, Joanna H.J. Tan, Adiam W. Bahta, Bryan Ho, Xingliang Liu, Tze Chwan Lim, Yee Yen Sia, Paul L. Bigliardi, Stefanie Heilmann, Andrew C.A. Wan, Markus M. Nöthen, Michael R. Philpott, Axel M. Hillmer

androgenetic alopecia dermal papilla cells gene expression balding non-balding scalps candidate genes AGA risk loci AGA DPCs

TLDR New genes found linked to balding, may help develop future treatments.

This study aimed to identify new candidate genes for androgenetic alopecia (AGA) by comparing gene expression in human dermal papilla cells (DPCs) from balding and non-balding scalps. The researchers found differentially expressed genes in balding DPCs compared to non-balding DPCs, some of which were previously associated with AGA risk loci. The study suggests that these genes may play a role in the development of AGA and could be potential targets for future treatments. The study provides new insights into the genetic basis of AGA and sheds light on the functional understanding of AGA biology.

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Research cited in this study

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