Six Novel Susceptibility Loci for Early-Onset Androgenetic Alopecia and Their Unexpected Association with Common Diseases

    May 2012 in “ PLOS Genetics ”
    Rui Li, Felix F. Brockschmidt, Amy K. Kiefer, Hreinn Stefansson, Dale R. Nyholt, Kijoung Song, Sita H. Vermeulen, Stavroula Kanoni, Daniel Glass, Andrew M. McIntosh, Maria Dimitriou, Dawn M. Waterworth, Joyce Y. Tung, Frank Geller, Stefanie Heilmann, Axel M. Hillmer, Veronique Bataille, Sibylle Eigelshoven, Sandra Hanneken, Susanne Moebus, Christine Herold, Martin den Heijer, Grant W. Montgomery, Panos Deloukas, Nicholas Eriksson, Andrew C. Heath, Tim Becker, Patrick Sulem, Massimo Mangino, Peter Vollenweider, Tim D. Spector, George Dedoussis, Nicholas G. Martin, Lambertus A. Kiemeney, Vincent Mooser, Kari Stefansson, David A. Hinds, Markus M. Nöthen, J. Brent Richards
    Image of study
    TLDR Six new genetic regions linked to early hair loss also connect to Parkinson's disease and prostate cancer, possibly leading to new treatments.
    This study identified six new genetic regions associated with early-onset androgenetic alopecia (AGA), a common form of hair loss. The study also found unexpected associations between these genetic regions and other common diseases, such as Parkinson's disease and prostate cancer. The researchers suggest that these findings could lead to new insights into the underlying causes of AGA and these other diseases, and potentially new treatments. The study involved a large number of participants and used genome-wide association analysis to identify the genetic regions.
    Discuss this study in the Community →

    Research cited in this study

    7 / 7 results

    Related Community Posts Join

    6 / 1000+ results

      community Hair loss research is a money grab

      in Chat  217 upvotes 3 weeks ago
      Hair loss is linked to DHT, with treatments like finasteride and minoxidil being common but not definitive. Economic interests influence research, and there is potential for new treatments like PP405 and RU58841.

      community It's always the Mice that gets to grow back hair.

      in Research/Science  431 upvotes 1 month ago
      Sodium dodecyl sulfate, oleic acid, and palmitoleic acid may promote hair growth, but their safety and effectiveness for humans are uncertain. Users consider trying these treatments cautiously, exploring alternatives like ostrich oil and microneedling.
      If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      in Research  830 upvotes 1 year ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community My Theory Of Androgenic Alopecia

      in Research/Science  17 upvotes 1 week ago
      Hair loss is linked to cellular physiology and the IGF-1 to TGF-B1 ratio, not just androgen sensitivity. The theory lacks evidence, while finasteride and minoxidil are effective treatments.

    Similar Research

    5 / 1000+ results