Androgenetic Alopecia: Pathogenesis and Potential for Therapy

November 2002 in “ Expert Reviews in Molecular Medicine ”

Justine A. Ellis, Rodney Sinclair, Stephen B. Harrap

androgenetic alopecia androgens androgen receptor minoxidil finasteride gene therapy Rogaine Propecia

TLDR Hair loss needs more research for better treatments.

This document from 20 years ago discusses androgenetic alopecia, a common form of hair loss that affects both men and women. The document explores the role of androgens and the androgen receptor in the condition, as well as potential therapies such as minoxidil and finasteride. The authors suggest that further research is needed to fully understand the pathogenesis of androgenetic alopecia and to develop more effective therapies. The document also discusses the potential genetic causes of androgenetic alopecia and the use of gene therapy as a treatment option.

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20 / 20 results

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research Advances in the Treatment of Male Androgenetic Alopecia: A Brief Review of Finasteride Studies

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Finasteride is effective in growing hair and stopping hair loss in men with mild to moderate alopecia.

research The Genetics of Androgenetic Alopecia

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research Female Androgenetic Alopecia: A Separate Entity

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Female and male AGA are different diseases.

research The Effects of Finasteride on Scalp Skin and Serum Androgen Levels in Men with Androgenetic Alopecia

65 citations , October 1999 in “Journal of The American Academy of Dermatology”

Finasteride effectively reduces hair loss by decreasing androgen levels.

research Clinical Dose Ranging Studies with Finasteride, a Type 2 5α-Reductase Inhibitor, in Men with Male Pattern Hair Loss

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Finasteride effectively treats male pattern hair loss with a 1 mg daily dose.

research The Psychosocial Consequences of Androgenetic Alopecia: A Review of the Research Literature

180 citations , September 1999 in “British Journal of Dermatology”

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research Serum Androgens and Genetic Linkage Analysis in Early Onset Androgenetic Alopecia

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research Fortnightly Review: Male Pattern Androgenetic Alopecia

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Hair loss in men is common, treatable, but not curable.

research Association of Benign Prostatic Hyperplasia with Male Pattern Baldness

54 citations , May 1998 in “Urology”

Men with enlarged prostates often have more severe baldness.

research Different Levels of 5α-Reductase Type I and II, Aromatase, and Androgen Receptor in Hair Follicles of Women and Men with Androgenetic Alopecia

416 citations , September 1997 in “Journal of Investigative Dermatology”

People with hair loss have more androgen receptors and enzymes in certain follicles, with men and women showing different patterns.

research THE USE OF DERMAL PAPILLA CELLS IN STUDIES OF NORMAL AND ABNORMAL HAIR FOLLICLE BIOLOGY

19 citations , October 1996 in “Dermatologic Clinics”

Dermal papilla cells are key for hair growth and could help us understand and treat hair loss.

research The effect of finasteride, a 5 alpha-reductase inhibitor, on scalp skin testosterone and dihydrotestosterone concentrations in patients with male pattern baldness.

59 citations , September 1994 in “The Journal of Clinical Endocrinology and Metabolism”

Finasteride reduces scalp DHT levels, potentially treating male pattern baldness.

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26 citations , January 1994 in “McGraw-Hill eBooks”

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research The psychological effects of androgenetic alopecia in men

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research Natural progression of male pattern baldness in young men

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research Topical minoxidil in male pattern baldness: Effects of discontinuation of treatment

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Stopping minoxidil treatment resumes balding; continuous use needed for results.

research Use of Topical Minoxidil in the Treatment of Male Pattern Baldness

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Minoxidil effectively regrows hair in male pattern baldness.

research Minoxidil for Severe Hypertension After Failure of Other Hypotensive Drugs

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Minoxidil effectively controls blood pressure in severe cases, but has serious side effects and causes hair growth in women.

9 / 9 results

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research Treatments of Hereditary Hair Loss (Alopecia)

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research Minoxidil to Treat Androgenetic Alopecia in Men and Women: What Is It and How Does It Work?

January 2014 in “American Journal of Medicine and Medical Sciences”

Minoxidil, originally a blood pressure medication, is effective in treating hair loss in men and women, with different strengths recommended for each.

research Disorders of Hair

July 2013 in “DeckerMed Medicine”

The document's conclusion cannot be provided because the document is not readable or understandable.

research Characteristics of Korean Scalp Hair and Male Pattern Baldness

January 2013 in “Journal of The Korean Medical Association”

The document's conclusion cannot be provided because the text is in Korean and cannot be parsed.

research Androgenetic Alopecia: Pathogenesis and Potential for Therapy

174 citations , November 2002 in “Expert Reviews in Molecular Medicine”

Hair loss needs more research for better treatments.

research CLINICAL UPDATES IN HAIR

19 citations , January 1997 in “Dermatologic Clinics”

Most treatments for hair loss in 1997 were not effective for most people, and maintaining hair growth was difficult.