Serum Androgens and Genetic Linkage Analysis in Early Onset Androgenetic Alopecia

August 1999 in “ Journal of Investigative Dermatology ”

G. P. Sreekumar, Jose Pardinas, Ching-Ping Wong, David A. Whiting, H. Irving Katz, Vera H. Price, Abraham Zlotogorski, Jay Roberts, Benton C. Clark, Kurt S. Stenn, Satish Parimoo

androgenetic alopecia androgen receptor gene type II 5 alpha reductase serum androgen levels genetic linkage analysis androgen metabolism AGA androgen receptor 5 alpha reductase androgen levels

TLDR Early onset hair loss linked to genetics and androgen levels.

The document titled "Serum Androgens and Genetic Linkage Analysis in Early Onset Androgenetic Alopecia" discusses the causes of androgenetic alopecia (AGA) and proposes various genetic models to explain its development. The study found a significant association between early onset AGA and the androgen receptor gene through genetic linkage analysis on 45 families. The study also suggests that males deficient in type II 5 alpha reductase enzyme do not develop AGA, indicating the role of genetic factors and androgen metabolism in the development of AGA. The study investigated the relationship between serum androgen levels and early onset AGA and found a potential genetic component to the condition. The study suggests that targeting androgen levels may be a potential treatment for AGA.

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Different Levels of 5α-Reductase Type I and II, Aromatase, and Androgen Receptor in Hair Follicles of Women and Men with Androgenetic Alopecia

research Different Levels of 5α-Reductase Type I and II, Aromatase, and Androgen Receptor in Hair Follicles of Women and Men with Androgenetic Alopecia

416 citations, September 1997 in “Journal of Investigative Dermatology”

People with hair loss have more androgen receptors and enzymes in certain follicles, with men and women showing different patterns.

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community The Real Cause Of Androgenetic Alopecia

in Research/Science 667 upvotes 1 month ago

Androgenetic alopecia is caused by DHT affecting hair growth. Finasteride and minoxidil are used to manage hair loss by blocking DHT and promoting hair growth.

community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 3 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community Testosterone and hair loss seeming irrelevance

in Research/Science 81 upvotes 1 year ago

The conversation is about the role of testosterone in hair loss and the effectiveness of different treatments. The conclusion is that DHT is the main culprit for hair loss, and finasteride has been proven to work long-term in maintaining and regrowing hair. Testosterone may have a minor effect, but it is not the primary cause of hair loss.

community Dutasteride SAVES your hair follicles: MAJOR BS on people who say it destroyed their hair permanently.

in Finasteride/Dutasteride 156 upvotes 11 months ago

The conversation discusses the effectiveness of hair loss treatments, specifically finasteride and dutasteride. The conclusion is that dutasteride significantly reduces DHT levels and may be more effective than finasteride for long-term hair retention, with some users reporting personal experiences and side effects.

community DHT/Testosterone levels in scalp Fin VS Dut.

in Finasteride/Dutasteride 60 upvotes 4 months ago

Dutasteride raises scalp testosterone by 99%, which may not be ideal for those sensitive to all androgens. Some argue finasteride's balancing act might be better, while others believe dutasteride is superior for hair regrowth.