A Hypothetical Pathogenesis Model for Androgenic Alopecia: Clarifying the Dihydrotestosterone Paradox and Rate-Limiting Recovery Factors

December 2017 in “ Medical Hypotheses ”

Robert S. English

androgenic alopecia dihydrotestosterone DHT hair follicle miniaturization tissue remodeling capillary network calcification sebaceous gland enlargement microvascular deficiency scalp tension androgens arterial calcification fibrosis transforming growth factor beta-1 TGF-ß1 AGA

Studysummary This review evaluates dihydrotestosterone's role in androgenic alopecia and proposes a model suggesting that chronic scalp tension and inflammation contribute to hair follicle miniaturization, identifying fibrosis, calcification, and tension as treatment targets.

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