The AR/miR-221/IGF-1 Pathway Mediates the Pathogenesis of Androgenetic Alopecia

January 2023 in “ International Journal of Biological Sciences ”

Kaitao Li, Ying Sun, Shizhao Liu, Yi Zhang, Qian Qu, Gaofeng Wang, Jin Wang, Ruosi Chen, Zhexiang Fan, Bingcheng Liu, Yuning Li, Xiaoyan Mao, Zhiqi Hu, Yong Miao

androgenetic alopecia miR-221 androgen receptor IGF-1 dermal papilla cells dermal sheath cells MAPK pathway PI3K/AKT pathway AGA insulin-like growth factor 1

Studysummary In this study, miR-221 was identified as a key factor in androgenetic alopecia pathogenesis due to its role in suppressing hair growth by interacting with androgen receptors and affecting related pathways.

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